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折扣/货期| 货号：CDX-T0207-G001 | 规格：1 g | 目录价：￥1960 |
产品详情
产品名称:
Terbinafine hydrochloride
别名:
trans-N-(6,6-Dimethyl-2-hepten-4-ylyl)-N-methyl-1-naphthylmethylamine hydrochloride; N-[(2E)-6,6-dimethyl-2-hepten-4-yn-1-yl]-N-methyl-1-naphthalenemethanamine hydrochloride
产品描述:
Terbinafine is an antifungal and antimycotic compound that is highly active against dermatophytes, mold, other basic fungi, and some strains of yeast. It is clinically used to treat nail and skin infections. Inhibits ergosterol synthesis, essential component of fungal cell membranes. Potent non-competitive inhibitor at the stage of squalene epoxidation (IC50=30nM for C. albicans). Selective activator of the K2P channel TASK3 (pEC50 = 6.2). Exhibits >10-fold selectivity for TASK3 over TREK2, TRESK, THIK1 and TASK2. Also inhibits TWIK1 (pIC50 = 5.69). K2P channels might also be a target for ist antifungal activity. Shown to exhibit at higher concentrations anti-tumor and anti-angiogenic activity by inducing cell cycle arrest, and to display interesting anti-inflammatory and free radical scavenging activities.
宿主来源:
Synthetic
保存温度:
-20°C
运输温度:
Ambient
预期分子量:
291.4 . 36.5
产品形式:
solid
有效期:
Stable for at least 2 years after receipt when stored at -20°C.
产地:
瑞士
纯度:
>98% (HPLC)
CAS号:
78628-80-5
分子式:
C21H25N . HCl
溶解度:
Soluble in ethanol (30mg/ml), DMSO (10mg/ml), DMF (10mg/ml), methanol (50 mg/ml). Sparingly soluble in acetone or water.
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