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Tamoxifen citrate salt

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：CDX-T0201-G001	规格：1 g	目录价：￥询价
货号：CDX-T0201-G005	规格：5 g	目录价：￥询价

产品详情

产品名称:

Tamoxifen citrate salt

别名:

(Z)-1-(p-Dimethylaminoethoxyphenyl)-1,2-diphenyl-1-butene; ICI 46474; Istubal; Kessar; Noltam; Nolvadex; TMX; Valodex; Zemide

产品描述:

Selective estrogen receptor modulator (SERM) used as adjuvant therapy for estrogen-dependent breast cancer. Antagonist of ER action in breast tissue and breast cancer cells and ER agonist in bone, uterus, and the cardiovasculature system. This prodrug is metabolized by cytochrome P450 (CYP450) enzymes to the active metabolites N-desmethyl-TMX, 4-hydroxy-N-desmethyl-TMX (endoxifen) and 4-hydroxy-TMX (afimoxifene). N,N-Didesmethyl-4-hydroxytamoxifen (norendoxifen), another active metabolite has been found to act as a potent competitive aromatase inhibitor and may also be involved in its antiestrogenic activity. Binds microsomal antiestrogen binding sites, altering cholesterol esterification at therapeutic doses and impacting breast cancer cell differentiation, apoptosis, and autophagy. Protein kinase C (PKC) inhibitor and anti-angiogenetic factor.

保存温度:

+4°C

运输温度:

Ambient

预期分子量:

563.64

产品形式:

solid

有效期:

Stable for at least 2 years after receipt when stored at +4°C.

产地:

瑞士