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Monophosphoryl Lipid A [MPLA] from E. coli R515 (Re) TLRpure Sterile Solution
品牌：Adipogen
货号：IAX-100-003-C250 规格：250 ug 目录价：￥2114
货号：IAX-100-003-C500 规格：500 ug 目录价：￥2954
货号：IAX-100-003-M001 规格：1 mg 目录价：￥5082
产品详情
产品名称:
Monophosphoryl Lipid A [MPLA] from E. coli R515 (Re) TLRpure Sterile Solution
别名:
Monophosphoryl Lipid A [MPLA] derived from E. coli R515 (Re) LPS (biosesynthetic)
产品描述:
Activation of cells by LPS is mediated by the Toll-like receptor 4 (TLR4), a member of the highly conserved protein family of TLRs, which are specialised in the recognition of microbial components. In mice, defects in TLR4 result in LPS unresponsiveness. For optimal interaction with LPS, TLR4 requires association with myeloid differentiation protein 2 (MD-2). According to current consensus activation of TLR4 is preceded by the transfer of LPS to membrane-bound (m) or soluble (s) CD14 by LPS-binding protein (LBP). This mechanism is believed to be generally true for LPS signaling. Re-form LPS and lipid A, but not S-form LPS, are capable of inducing TNF-alpha responses also in the absence of CD14. LPS, synthesized by most wild-type (WT) Gram-negative bacteria (S-form LPS), consists of three regions, the O-polysaccharide chain, which is made up of repeating oligosaccharide units, the core oligosaccharide and the lipid A, which harbors the endotoxic activity of the entire molecule. R-form LPS synthesized by the so-called rough (R) mutants of Gram-negative bacteria lacks the O-specific chain. Furthermore, the core-oligosaccharide may be present in different degrees of completion, depending on the class (Ra to Re) to which the mutant belongs. Monophosphoryl Lipid A (MPLA) represents a detoxified derivative of Lipid A and constitutes an important adjuvant in prophylactic and therapeutic vaccines.
宿主来源:
Isolated and purified from E. coli strain R515.
产品浓度:
1mg/ml (0.5mg/ml for 250µg size) stabilised in sterile, double-distilled water (ddWater), without any additives.
保存温度:
+4°C
运输温度:
Ambient
产品形式:
liquid
存储溶液:
Liquid. Colourless opaque aqueous solution.
有效期:
Stable for at least 2 years after receipt when stored at +4°C.
产地:
瑞士
纯度:
>99.9%. No detectable DNA, RNA and protein traces.
生物活性:
Optimal concentration is dependent upon cell type, species, desired activation and analysis: 0.1-1.0µg/ml. Does not activate any TLR other than TLR4 as tested up to 50µg/ml in relevant cellular systems (macrophages).
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