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Kdo2-Lipid A (ready-to-use)
品牌：Adipogen
货号：AG-CU1-0001-M001 规格：1 mg 目录价：￥1800
产品详情
产品名称:
Kdo2-Lipid A (ready-to-use)
别名:
(3-Deoxy-D-manno-octulosonic acid)2-Lipid A
产品描述:
Defined substructure of the Re mutant of lipopolysaccharide (LPS) [1]. Endotoxin activity equal to Re LPS [1]. Strong activator (<10ng/ml) of macrophages via toll-like receptor 4 (TLR4) [1, 2, 3, 4, 9]. Does not activate TLR2 [5] or other TLRs as determined with splenocytes and macrophages from TLR4 deficient mice by IL-6 ELISA [1,4]. Facilitates the structural analysis of its complexes with signaling receptors, such as TLR4/MD2 [1,2] and CD14 [7]. Kdo2-Lipid A was used in a recent animal atherosclerosis model [6]. Induces sphingolipid biosesynthesis, which is essential for induction of autophagy [8].
宿主来源:
Isolated and purified from E. coli K12 heptose-deficient strain WBB06 (Re mutant).
产品浓度:
0.5mg/ml. Vial contains 2 ml.
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
2326.7
产品形式:
liquid
存储溶液:
Liquid. Sterile, ready-to-use solution in pyrogen-free double distilled water.
有效期:
Stable for at least 2 years after receipt when stored at +4°C.
产地:
瑞士
纯度:
Absence of detectable protein or DNA contaminants with agonistic TLR activity.
CAS号:
123621-04-5 (free base)
分子式:
C110H198N2Na4O39P2
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