Aloxistatin [E-64d]-抑制剂-ELISA_抗体_蛋白_核苷酸_试剂盒-深圳九游会j9网站首页有限公司

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Aloxistatin [E-64d]

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：AG-CR1-3737-M001	规格：1 mg	目录价：￥360
货号：AG-CR1-3737-M005	规格：5 mg	目录价：￥960
货号：AG-CR1-3737-M025	规格：25 mg	目录价：￥2880

产品详情

产品名称:

Aloxistatin [E-64d]

别名:

E-64c ethyl ester; EP 453; EST; Loxistatin

产品描述:

Aloxistatin [E-64d] is a cell permeable irreversible inhibitor of lysosomal and cytosolic cysteine proteases cathepsin B an L, calpain 1/2, papain and has diverse biological activities. It is an ethyl ester form of E-64c that inhibits calpain and the cysteine proteases cathepsins F, K, B, H, and L. Aloxistatin has anticancer properties by inducing cell cycle arret at the G2/M phase in A431 human epidermoid carcinoma cells and as a lysosomal inhibitor in human acute promyelocytic leukemia NB4 cells and Huh-7 cells. It inhibits degradation of autophagic cargo inside autolysosomes. It also shows neuroprotective and anti-malarial properties. Since cysteine protease cathepsin L is required for SARS-CoV-2 viral entry, aloxistatin treatment reduces cellular entry of SARS-CoV-2 pseudovirions and COVID-19. It inhibits severe acute respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2 surface glycoprotein incorporation into pseudotyped vesicular stomatitis virus (VSV) particles in Vero cells. Is has been applied in vitro in combination with the TMPRSS2 inhibitor camostat mesylate (Prod. No. AG-CR1-3716).

保存温度:

-20°C

运输温度:

Ambient

预期分子量:

342.4

产品形式:

solid

有效期:

Stable for at least 2 years after receipt when stored at -20°C.

产地:

瑞士