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折扣/货期| 货号：26345 | 规格：100 µg | 目录价：￥6720 |
产品详情
产品名称:
YTHDF2 (human recombinant)
别名:
CAHL|CLL-associated Antigen KW-14|HGRG8|High-Glucose-Regulated Protein 8|Renal Carcinoma Antigen NY-REN-2|YTH Domain-containing Family Member 2|YTH N6-Methyladenosine RNA Binding Protein 2 (358-502; YTH domain)
产品描述:
YTH-Domain family member 2 (YTHDF2) is a reader protein that binds to N6-methyladenosine (m6A) to regulate mRNA degradation.{42713,42714} YTHDF2 binds to m6A sites in the 3'-UTR of mRNA through its C-terminal YTH domain and recruits the CCR4-NOT deadenylase complex via its N-terminus to accelerate mRNA localization to decay sites, such as P-bodies, and promote subsequent degradation.{42713,42714,35631} Ythdf2 knockout results in a build-up of maternal mRNA in oocytes that induces female-specific infertility in mice.{42715} Conditional knockout of Ythdf2 increases the number of hematopoietic stem cells (HSCs) without shifting lineage differentiation or inducing malignancies.{42716} It also increases ex vivo expansion of human umbilical cord HSCs. This product is the C-terminus of YTHDF2 corresponding to residues 358-502 of the human full-length sequence.
保存温度:
-80
运输温度:
-80
产品形式:
50 mM HEPES, pH 7.5, with 150 mM sodium chloride and 10% glycerol
有效期:
365
纯度:
≥90% estimated by SDS-PAGE
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