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折扣/货期| 货号：26306 | 规格：5 Kunits | 目录价：￥11480 |
产品详情
产品名称:
COX-1 (human, recombinant; mammalian expressed)
别名:
Cyclooxygenase 1|PGHS-1|Prostaglandin Endoperoxide Synthase 1|Prostaglandin G/H Synthase 1|Prostaglandin H2 Synthase 1
产品描述:
Cyclooxygenase 1 (COX-1) is a bifunctional enzyme that exhibits both COX and peroxidase activities.{500,501} It is composed of an N-terminal signal peptide, an EGF-like domain, a membrane binding domain, a catalytic domain, and a C-terminal tail.{4376} COX-1 is constitutively expressed in the gastrointestinal tract, kidney, spleen, liver, and lung and localizes to the endoplasmic reticulum.{1299,1394} The COX component converts arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) to a hydroperoxyl endoperoxide prostaglandin G2 (PGG2; Item No. 17010) and the peroxidase component reduces the endoperoxide to the corresponding alcohol PGH2 (Item No. 17020), the precursor of PGs, thromboxanes, and prostacyclins.{500,501} COX-1 is the target of many non-steroidal anti-inflammatory drugs (NSAIDs) and is responsible for the undesirable gastrointestinal and renal side effects, such as ulcer formation and reductions in the glomerular filtration rate, respectively.{5282,4411} Cayman’s COX-1 (human, recombinant; mammalian expressed) protein can be used for enzyme activity assays.
保存温度:
-80
运输温度:
-80
产品形式:
80 mM Tris, pH 8.0, with 0.3 mM diethyldithiocarbamic acid (DDC), 0.01% Tween 20, and 10% glycerol
有效期:
365
纯度:
≥80% estimated by SDS-PAGE
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