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折扣/货期| 货号：10004224-100 µg | 规格：100 µg | 目录价：￥2408 |
| 货号：10004224-25 µg | 规格：25 µg | 目录价：￥686 |
| 货号：10004224-50 µg | 规格：50 µg | 目录价：￥1288 |
| 货号：10004224-500 µg | 规格：500 µg | 目录价：￥10612 |
产品详情
产品名称:
trans-EKODE-(E)-Ib
别名:
12,13-epoxy-9-keto-10(trans)-Octadecenoic Acid
产品描述:
During oxidative stress, the abundant unsaturated fatty acid linoleic acid undergoes lipid peroxidation to produce α,β-unsaturated epoxy-keto-octadecenoic acids (EKODEs). Nonenzymatic autooxidation of linoleic acid generates six major EKODE isomers, which differ from one another in the positioning and the orientation of the epoxy group relative to the keto moiety. trans-EKODE-(E)-Ib is a biologically active peroxidation product of linoleic acid that is characterized, structurally, by having a trans carbon-carbon double bond between the 9-keto and 12,13-epoxy groups. It activates an antioxidant response element (ARE) in neuronal cells and induces the expression of ARE-regulated cytoprotective genes like NQO1.{17702} This EKODE also stimulates the synthesis of aldosterone and corticosterone in adrenal cells when supplied at 1-5 μM.{17699,17700} This effect appears to be mediated by a rise in intracellular calcium.{17701}
保存温度:
-20
运输温度:
-20
预期分子量:
310.4
产品形式:
A solution in ethanol
有效期:
365
纯度:
≥98%
CAS号:
478931-82-7
分子式:
C18H30O4
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