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15(R)-Lipoxin A4
品牌:Cayman
货号:90415-100 µg 规格:100 µg 目录价:¥10108
货号:90415-25 µg 规格:25 µg 目录价:¥2814
货号:90415-250 µg 规格:250 µg 目录价:¥22414
货号:90415-50 µg 规格:50 µg 目录价:¥5348
产品详情
产品名称:
15(R)-Lipoxin A4
别名:
15(R)-LXA4|15-epi Lipoxin A4|AT-Lipoxin A4
产品描述:
Lipid-derived lipoxins are produced at the site of vascular and mucosal inflammation where they down-regulate polymorphonuclear leukocyte recruitment and function. 15(R)-Lipoxin A4 (15(R)-LXA4) is derived from the aspirin-triggered formation of 15(R)-HETE (Item No. 34710) from arachidonic acid (Item No. 90010).{3520,2629} 15(R)-LXA4 inhibits LTB4-induced chemotaxis, adherence, and transmigration of neutrophils with twice the potency of LXA4 (Item No. 90410) demonstrating activity in the nM range.{2629,11078} The anti-inflammatory effects of aspirin may be ascribed in part to the ability of 15(R)-LXA4 to regulate leukocyte function.{15182} 15(R)-LXA4 is reported to promote resolution of inflammation in LPS-treated stromal cells derived from intermediate-stage diseased supraspinatus tendons as evidenced by increased expression of the STAT-6 pathway target genes, ALOX15 and CD206.{29947}
保存温度:
-80
运输温度:
-80
预期分子量:
352.5
产品形式:
A solution in ethanol
有效期:
365
纯度:
≥95%
CAS号:
171030-11-8
分子式:
C20H32O5
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