官网链接
折扣/货期| 货号：AG-CR1-3741-M010 | 规格：10 mg | 目录价：￥1080 |
| 货号：AG-CR1-3741-M050 | 规格：50 mg | 目录价：￥3240 |
| 货号：AG-CR1-3741-M250 | 规格：250 mg | 目录价：￥8280 |
产品详情
产品名称:
Telaprevir
别名:
VX-950; LY570310; MP-424
产品描述:
The antiviral agent telaprevir is a covalent, reversible inhibitor of hepatitis C virus (HCV) nonstructural protease 3/4A (NS3/4A; Ki = 7nM), a serine protease that is essential for viral replication by cleaving the virally encoded polyprotein into mature proteins like NS4A, NS4B, NS5A and NS5B, leading to inhibition of viral polyprotein processing and subsequently decrease of viral RNA replication. It inhibits viral replication in genotype 1b HCV replicon cells (IC50 = 354nM) and isolated human fetal hepatocytes infected with genotype 1a HCV-positive patient sera (IC50 = 280nM). Used in stabilizable polypeptide linkages (StaPLs) chemogenetic platform, for pharmacological regulation of protein expression/function. StaPL sequences can be engineered into target proteins rendering them functional only in the presence of telaprevir. Telaprevir has been identified as a potential inhibitor of SARS-CoV-2, responsible for COVID-19. It inhibits SARS-CoV-2 viral replication by targeting the viral 3C-like Protease (3CLpro), interacting through hydrogen bond formation with Ser46 and Gln182 main chain amines as well as Glu166 alpha-carboxyl group.
保存温度:
-20°C
运输温度:
Ambient
预期分子量:
679.9
产品形式:
solid
有效期:
Stable for at least 2 years after receipt when stored at -20°C.
产地:
瑞士
纯度:
>95% (HPLC)
CAS号:
402957-28-2
分子式:
C36H53N7O6
溶解度:
Soluble in DMSO (10mg/ml) or DMF.
您可能感兴趣的产品
Caspase-9 Inhibitor, Z-LE(OMe)HD(OMe)-FMK
货号：GTX47945
Caspase Family Inhibitor, Z-VAD(OMe)-FMK
货号：GTX47941
Olaparib
货号：CDX-O0144-M100
Oxyresveratrol
货号：CDX-O0035-M100
1-Methyltryptamine
货号：CDX-M0138-M200
Hydramethylnon
货号：CDX-H0096-M100
Cabozantinib S-malate
货号：CDX-C0698-M100
Chlornitrofen
货号：CDX-C0233-M250
促销活动
精品推荐
