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折扣/货期| 货号：CDX-T0455-M050 | 规格：50 mg | 目录价：￥980 |
| 货号：CDX-T0455-M500 | 规格：500 mg | 目录价：￥6202 |
产品详情
产品名称:
Tadalafil
别名:
GF196960; (6R,12aR)-6-(1,3-Benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methylpyrazino[1,2:1,6]pyrido[3,4-b]indole-1,4-dione
产品描述:
Tadalafil is a potent long-acting and selective inhibitor of the cGMP specific phosphodiesterase 5 (PDE5; IC50 = 1.2 nM). It is selective for PDE5 over PDE1-4 and 7-10 (IC50s = 9.2-280 µM), however, it does also inhibit PDE11 (IC50 = 11 nM). In vivo, tadalafil (10 mg/kg) decreases production of the proinflammatory cytokines TNF-alpha, IL-1beta, and IL-6 and improves renal function in a rat model of ischemia/reperfusion injury. Formulations containing tadalafil have been used to treat erectile dysfunction, pulmonary arterial hypertension, benign prostatic hyperplasia (BPH) and lower urinary tract dysfunction. Also delays tumor growth in a mouse model via inhibition of MDSC-mediated immunosuppression.
保存温度:
-20°C
运输温度:
Ambient
预期分子量:
389.4
产品形式:
solid
有效期:
Stable for at least 2 years after receipt when stored at -20°C.
产地:
瑞士
纯度:
>98%
CAS号:
171596-29-5
分子式:
C22H19N3O4
溶解度:
Soluble in DMSO (20mg/ml) or DMF (25mg/ml).
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