SMN Monoclonal Antibody (Clone 4B7)-单抗-ELISA_抗体_蛋白_核苷酸_试剂盒-深圳九游会j9网站首页有限公司

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SMN Monoclonal Antibody (Clone 4B7)

品牌：Cayman

官网链接

说明书

折扣/货期

货号：29295

规格：100 µl

目录价：￥7760

产品详情

产品名称:

SMN Monoclonal Antibody (Clone 4B7)

别名:

Gemin-1|Survival Motor Neuron Protein

产品描述:

The survival motor neuron (SMN) protein is a ubiquitously expressed, multifunctional protein with roles in a variety of cellular processes, including small nuclear ribonucleoprotein (snRNP) and spliceosome assembly, translation, cytoskeletal dynamics, and stress granule formation.{56204,56205} It is a 294-amino acid protein encoded by SMN1 in humans and is comprised of an N-terminal basic/lysine-rich domain that interacts with RNA and Gemin-2, a central Tudor domain (Item No. 14136) that functions in a variety of protein-protein interactions, a proline-rich region, and a C-terminal YG box that facilitates SMN oligomerization. Humans also have a second centromeric copy of the gene, called SMN2, that is the result of duplication and inversion and primarily produces a truncated isoform, SMNΔ7, which is less stable, but can also produce small amounts of SMN. Knockout of Smn is embryonic lethal in mice.{56204} In humans, mutations in SMN1 are associated with spinal muscular atrophy (SMA), a neuromuscular disorder characterized by degeneration of α motor neurons in the spinal cord and muscle weakness. Cayman's SMN Monoclonal Antibody can be used for immunocytochemistry (ICC) and Western blot (WB) applications. The antibody recognizes SMN protein at approximately 35 kDa from human, mouse, and rat samples.

宿主来源:

Mouse

实验应用:

ICC, WB

同种型:

IgG1

免疫原:

Recombinant human His-tagged SMN protein expressed in E. coli. The epitope recognized by the 4B7 clone binds to the region encoded by exon 1.

克隆号:

4B7

保存温度:

-20