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折扣/货期| 货号：35564-10 mg | 规格：10 mg | 目录价：￥1484 |
| 货号：35564-25 mg | 规格：25 mg | 目录价：￥3486 |
| 货号：35564-5 mg | 规格：5 mg | 目录价：￥784 |
| 货号：35564-50 mg | 规格：50 mg | 目录价：￥6174 |
产品详情
产品名称:
Setmelanotide (trifluoroacetate salt)
别名:
BIM-22493|N-acetyl-RCAHFRWC-NH2|RM-493
产品描述:
Setmelanotide is a cyclic peptide agonist of melanocortin receptor 4 (MC4R).{66000} It increases cAMP production in CHO-K1 cells expressing MC4R, MC1R, MC3R, and MC5R (EC50s = 0.27, 5.8, 5.3, and 1,600 nM, respectively, for the human receptors) but not in cells expressing MC2R (EC50 = >10 µM). Setmelanotide (6.4 µmol/animal) inhibits food intake in MC3R, but not MC4R, knockout mice. It also reduces food intake and hepatosteatosis, induces weight loss, and decreases serum insulin, glucose, and leptin levels in a mouse model of diet-induced obesity when administered at a dose of 300 nmol/kg per day. Formulations containing setmelanotide have been used in chronic weight management due to proopiomelanocortin (POMC), proprotein convertase subtilisin/kexin type 1 (PCSK1), or leptin receptor deficiency.
保存温度:
-20
运输温度:
-20
预期分子量:
1117.3
产品形式:
A solid
有效期:
1460
纯度:
≥98%
分子式:
C49H68N18O9S2 • XCF3COOH
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