SCF Extracellular Domain (human, recombinant)

c-Kit Ligand|Kit Ligand|Mast Cell Growth Factor|MGF|Steel Factor|Stem Cell Factor

Stem cell factor (SCF), also known as steel factor or c-Kit ligand, is a growth factor and cytokine that promotes proliferation, migration, survival, and differentiation of hematopoietic progenitors, germ cells, and melanocytes and is encoded by KITLG in humans.{54153} It is composed of an extracellular domain that contains a c-Kit binding region, a transmembrane domain, and a C-terminal intracellular tail and is ubiquitously expressed by fibroblasts and endothelial cells. SCF also exists as a soluble form produced by proteolytic cleavage of a membrane-bound isoform of SCF produced by alternative splicing and lacking exon 6. Both membrane-bound and soluble SCF homodimerize and bind to the SCF receptor, also known as c-Kit, to induce intracellular signaling. Allergen exposure increases lung and serum levels of SCF in a mouse model of allergic inflammation, and airway levels of SCF are increased in patients with asthma.{54152} Exogenous administration of SGF decreases infarct size and improves motor function in a spontaneously hypertensive rat model of stroke induced by middle cerebral artery occlusion.{54154} SCF inhibits apoptosis of CD34+ acute myeloid leukemia cells induced by cytarabine (Item No. 16069), daunorubicin (Item No. 14159), or carboplatin (Item No. 13112).{54155} Cayman's SCF Extracellular Domain (human, recombinant) protein can be used for cell-based assay applications. This protein consists of 175 amino acids, has a calculated molecular weight of 19.9 kDa, and a predicted N-terminus of Glu26 after signal peptide cleavage.

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Lyophilized from sterile 20 mM Tris, 500 mM sodium chloride, pH 8.0

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≥92% estimated by SDS-PAGE