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Santacruzamate A

品牌：Stressmarq

官网链接

说明书

折扣/货期

货号：SIH-613-5MG

规格：5 mg

目录价：￥1224

产品详情

产品名称:

Santacruzamate A

别名:

N-[4-Oxo-4-[(2-phenylethyl)amino]butyl]-carbamic acid, ethyl ester

产品描述:

Ultrapotent HDAC2 inhibitor

保存温度:

-20ºC

运输温度:

Shipped Ambient

预期分子量:

278.4

产地:

加拿大

功能与背景:

Santacruzamate A is a highly potent and selective inhibitor of HDAC2 isolated from the Panamanian marine cyanobacterium cf. Symploca (IC50=0.119 and 434 nM for HDAC2 and HDAC6 respectively) (1). It induces apoptosis and cancer cell death only in combination with other HDAC1 inhibitors (2). It has been been investigated as a potential therapeutic agent for breast cancer (3). Attenuates A fragment (A25-35)-induced toxicity in PC12 cells by enhancing ER stress tolerance4. Ameliorates Alzheimer’s disease-like pathology in mouse models (4).

纯度:

>98% (TLC); NMR (Conforms)

来源:

Synthetic

CAS号:

1477949-42-0

分子式:

C15H22N2O3

溶解度:

May be dissolved in DMSO (25 mg/ml); or Ethanol (20 mg/ml)

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