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折扣/货期| 货号：10765 | 规格：250 µg | 目录价：￥5026 |
产品详情
产品名称:
RIZ1 (human recombinant)
别名:
KMT8|PR Domain Zinc Finger Protein 2|PRDM2|Retinoblastoma Protein-interacting Zinc Finger Protein
产品描述:
Retinoblastoma protein-interacting zinc finger protein 1 (RIZ1), also known as PRDM2, is a SAM-dependent histone methyltransferase that specifically methylates histone H3 on lysine 9. RIZ1 contains 8 zinc-finger motifs and 1 PR domain.{20859,20860} The RIZ gene encodes two different proteins, RIZ1 and RIZ2. RIZ1 is a tumor suppressor that can arrest the cell cycle and induce apoptosis. RIZ2 however, is a proto-oncoprotein lacking the N-terminal PR domain containing the methyltransferase activity.{20858} When RIZ1 is silenced or mutated, the reduced methyltransferase activity can lead to inheritable changes in chromatin methylation and gene expression patterns.{20857}
保存温度:
-80
运输温度:
-80
有效期:
180
纯度:
≥85% estimated by SDS-PAGE
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