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折扣/货期| 货号：10658 | 规格：100 µg | 目录价：￥4830 |
产品详情
产品名称:
MLL1 (human recombinant)
别名:
ALL1|CXXC-type zinc finger protein 7|HRX|KMT2a|Lysine Methyltransferase 2A|Mixed Lineage Leukemia 1
产品描述:
Mixed Lineage Leukemia (MLL1) plays a major role in epigenetic regulation through methylation of histone 3 at lysine 4 (H3K4) to activate gene transcription. Methylation of H3K4 leads to upregulation of developmental genes, including HOX family members.{20268} In addition to its methylation activity, MLL1 has been shown to co-localize with Pol II at several genomic elements.{20269} Consequently, MLL1 has very low basal methyltransferase activity unless complexed with the activating protein complex of WDR5, Ash2L, and RbBP5 (MLL/WAR complex).{20270} This C-terminal fragment of MLL1, residues 3762 - 3969, contains the SET1 domain for methyltransferase activity, and the WIN motif for binding the WAR complex. The protein DPY-30 has also been reported to associate with the MLL1-WAR complex. MLL1 is also available as a component of the MLL1/WAR complex (Item No. 10756) and MLL1/WARD complex.
保存温度:
-80
运输温度:
-80
产品形式:
50 mM Tris, pH 8.0, with 400 mM sodium chloride, 10% glycerol, and 5 mM 2-mercaptoethanol
有效期:
180
纯度:
≥80% estimated by SDS-PAGE
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