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折扣/货期| 货号：313010-100 µg | 规格：100 µg | 目录价：￥1960 |
| 货号：313010-50 µg | 规格：50 µg | 目录价：￥1092 |
| 货号：313010-500 µg | 规格：500 µg | 目录价：￥8148 |
产品详情
产品名称:
Prostaglandin E1-d4
别名:
Alprostadil-d4|PGE1-d4
产品描述:
Prostaglandin E1-d4 (PGE1-d4) is intended for use as an internal standard for the quantification of PGE1 (Item No. 13010) by GC- or LC-MS. PGE1 is a vasoactive prostaglandin and an active metabolite of dihomo-γ-linolenic acid (DGLA; Item No. 90230).{64886,10906} It is formed from DGLA by COX-1 and COX-2. PGE1 is an agonist of the PGE2 (Item No. 14010) receptor subtypes EP1, EP2, EP3, and EP4, and the IP receptor (Kis = 36, 10, 1.1, 2.1, and 33 nM, respectively, for the mouse receptors).{6640} It inhibits ADP-induced platelet aggregation of isolated human platelet-rich plasma (IC50 = 40 nM) and isoproterenol-induced increases in L-type calcium current (ICa) in isolated rabbit atrial cells (EC50 = 27 nM).{960,9061} PGE1 (100 nM) induces vasodilation in isolated rat aortic rings and activates ATP-sensitive potassium channels (KATP) in a cell-attached patch clamp assay using isolated rat vascular smooth muscle cells (VSMCs).{64886} It decreases femoral arterial perfusion pressure in dogs.{1350} Formulations containing PGE1 have been used in the treatment of erectile dysfunction and to maintain patency of the ductus arteriosesus in neonates with congenital heart defects who depend on a patent ductus arteriosesus for survival.
保存温度:
-20
运输温度:
-20
预期分子量:
358.5
产品形式:
A solution in methyl acetate
有效期:
730
纯度:
≥99% deuterated forms (d1-d4)
CAS号:
211105-33-8
分子式:
C20H30D4O5
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