货号:10004942 | 规格:1 ea (200 µg) | 目录价:¥4410 |
产品详情
产品名称:
Nod2 Monoclonal Antibody (Clone 2D9)
别名:
Caspase Recruitment Domain-containing Protein 15|Inflammatory Bowel Disease Protein 1|Nucleotide-binding Oligomerization Domain-containing Protein 2
产品描述:
Nod2 is a member of the apoptosis regulating protein family that has caspase recruitment-domains (CARDs) and also includes Apaf-1 and Nod1.{8852} Nod2 contains two N-terminal CARDs, a nucleotide binding domain (NBD), and multiple C-terminal leucine-rich repeats (LRRs). Nod2 is expressed in monocytes whereas Nod1 (CARD4) is expressed in multiple tissues.{8852,12079,8407,12078} Both Nod1 and Nod2 act as intracellular receptors for bacterial lipopolysaccharides, activate NF-kB, and contribute to inflammatory bowel disease.{8407,8408,8855,8859} A frameshift mutation in the NOD2 gene is associated with susceptibility to Crohn’s disease, possibly by causing truncation of the tenth LRR.{8853,8854} Cayman Chemical’s NOD2 Monoclonal Antibody can be used for Western blot and immunohistochemical analysis of Nod2 on samples of human origin. The antibody will also recognize three Nod2 polymorphisms: L1007finsC, G908R, and R702W.{12079}
宿主来源:
Mouse
实验应用:
WB
同种型:
IgG1κ
免疫原:
Recombinant protein fragment from the internal region of human Nod2
克隆号:
2D9
保存温度:
-20
运输温度:
-20
产品形式:
200 μg of ammonium sulfate-purified monoclonal antibody
有效期:
365
来源:
Animal/Mouse
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