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    IL-1alpha (human) (rec.)
    品牌：Adipogen
    货号：CHI-HF-20001A-C010 规格：10 ug 目录价：￥2940
    产品详情
    产品名称:
    IL-1alpha (human) (rec.)
    别名:
    Interleukin-1alpha; IL-1F1; IL-1A
    产品描述:
    The most prominent members of the interleukin-1 (IL-1) superfamily are IL-1alpha and IL-1beta. They lack a signal peptide and are secreted by an unconventional, endoplasmic reticulum-Golgi-independent mechanism. IL-1alpha was reported to be more widely and constitutively expressed and has intracellular functions, but also acts locally in a membrane-bound form by activating IL-1R1. Additionally, passive release of IL-1alpha upon cell death can trigger a sterile inflammatory response to dying cells. The cleavage of IL-1alpha is not mediated by caspase-1 and is not required for binding to IL-1R1. Recently it has been observed that all activators of the inflammasome NLRP3/NALP3 induce the simultaneous secretion of IL-1alpha and IL-1beta. Although most activators fully rely on the inflammasome for IL-1alpha secretion, some induce the processing and secretion of IL-1alpha in an inflammasome-independent manner.
    宿主来源:
    HEK 293 cells
    保存温度:
    -20°C
    运输温度:
    BLUE ICE
    预期分子量:
    ~19kDa (SDS-PAGE)
    产品形式:
    solid
    存储溶液:
    Lyophilized from 0.2µm-filtered solution in PBS.
    有效期:
    Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
    产地:
    瑞士
    纯度:
    >95% (SDS-PAGE)
    生物活性:
    The ED50 as determined by the dose-dependent stimulation of murine D10S cells is < 0.001 ng/ml, corresponding to a specific activity of > 1 x 109units/mg.
    内毒素水平:
    <0.01EU/µg protein (LAL test; Lonza).
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