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    IgG3 (mouse) Rabbit Monoclonal Antibody (Clone RM218)
    货号：32098 规格：100 µg 目录价：￥6080
    产品详情
    产品名称:
    IgG3 (mouse) Rabbit Monoclonal Antibody (Clone RM218)
    别名:
    Immunoglobulin G3
    产品描述:
    Immunoglobulin G (IgG) is a member of the immunoglobulin superfamily of glycoproteins that plays a central role in the adaptive immune response.{28520} It is produced by B cells and later secreted by plasma cells and is the most abundant circulating antibody in human and mouse serum.{28520,55170,55174} IgG consists of two heavy chains of approximately 50 kDa each and two light chains of approximately 25 kDa each.{28520} The heavy chains are linked together by disulfide bonds to form an Fc region and also combine with the light chains to form the Fab region, which mediate receptor and antigen binding, respectively.{55171} IgG exists as four isotypes in mice: IgG1, IgG2b, IgG3, and, in a strain-specific manner, IgG2a or IgG2c.{55172,53858} IgG3 production is driven by bacterial- or viral-associated antigens, including HIV-1 and Staphylococcus antigens, and occurs early in the immune response following IgM class-switching.{55170,52653} IgG3 binds to and neutralizes pathogens, as well as activates complement and opsonizes bacteria, leading to complement-dependent cytotoxicity (CDC) and antibody-dependent cell cytotoxicity (ADCC), respectively. Serum IgG3 levels are increased in patients with primary biliary cirrhosis, Sjögren’s syndrome, systemic sclerosis, or systemic lupus erythematosus (SLE).{52654} Cayman’s IgG3 (mouse) Rabbit Monoclonal Antibody (Clone RM218) can be used for ELISA and Western blot (WB) applications. The antibody recognizes the Fab region of IgG3 from mouse samples.
    宿主来源:
    Rabbit
    实验应用:
    WB, ELISA
    同种型:
    IgG
    免疫原:
    Mouse IgG3
    克隆号:
    RM218
    保存温度:
    -20
    运输温度:
    -20
    产品形式:
    100 µg of protein A-affinity purified monoclonal antibody
    有效期:
    365
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