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折扣/货期| 货号：32005 | 规格：100 µg | 目录价：￥6080 |
产品详情
产品名称:
IgG2a (mouse) Monoclonal Antibody (Clone RM219)
别名:
Immunoglobulin G2a
产品描述:
Immunoglobulin G (IgG) is a member of the immunoglobulin superfamily of glycoproteins that plays a central role in the adaptive immune response.{28520} It is produced by B cells and later secreted by plasma cells and is the most abundant circulating antibody in human and mouse serum.{28520,55170,55174} IgG consists of two heavy chains of approximately 50 kDa each and two light chains of approximately 25 kDa each.{28520} The heavy chains are linked together by disulfide bonds to form an Fc region and also combine with the light chains to form the Fab region, which mediate receptor and antigen binding, respectively.{55171} IgG is produced following IgM class-switching in response to infection and is involved in numerous humoral host defense responses, including antibody-dependent cell-mediated cytotoxicity (ADCC), toxin neutralization, and pathogen opsonization.{55170} IgG exists as four isotypes in mice: IgG1, IgG2b, IgG3, and, in a strain-specific manner, IgG2a or IgG2c.{55172,53858} In vivo, class switching to the IgG2a isotype can happen via IFN-γ-dependent and -independent mechanisms, with the former resulting from the cognate interaction of B cells with T helper 1 (Th1) cells.{52651} IgG2a is the predominant isotype produced in response to infection with DNA or RNA viruses in mice.{52652} Cayman's IgG2a (mouse) Monoclonal Antibody (Clone RM219) can be used for ELISA and Western blot (WB; non-reducing conditions) applications. The antibody recognizes the Fc region of IgG2a from mouse samples at approximately 150 kDa.
宿主来源:
Rabbit
实验应用:
ELISA, WB (non-reducing conditions)
同种型:
IgG
免疫原:
Mouse IgG2a
克隆号:
RM219
保存温度:
-20
运输温度:
-20
产品形式:
100 µg of protein A-affinity purified monoclonal antibody
有效期:
365
上一个:IgG2aκ (mouse) Rabbit Monoclonal Antibody (Clone RM107)
下一个:ACE2 (human) Monoclonal Antibody (Clone AC384; preservative free)
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