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折扣/货期| 货号：32001 | 规格：100 µg | 目录价：￥6080 |
产品详情
产品名称:
Igκ Light Chain (mouse) Monoclonal Antibody (Clone RM103)
别名:
Immunoglobulin κ Light Chain
产品描述:
Igκ light chain is one type of light chain found in immunoglobulins, which are part of the immunoglobulin superfamily of glycoproteins that plays a central role in the adaptive immune response.{28520} Immunoglobulins are produced by B cells and later secreted by plasma cells as antibodies.{55225} They are composed of two heavy chains of approximately 50 kDa each and two light chains of approximately 25 kDa each.{28520} The heavy chains are linked together by disulfide bonds to form an Fc region and also combine with the light chains to form the Fab region, which mediate receptor and antigen binding, respectively.{55171} Mammalian immunoglobulins contain either Igκ or Igλ light chains, each of which are composed of a constant and variable domain.{28687} The ratio of Igκ to Igλ light chain-containing antibodies varies between species, with ratioses of 20:1, 2:1, and 1:20 in mice, humans, and cattle, respectively. Igκ and Igλ free light chains (FLCs) are produced during immunoglobulin synthesis, and accumulation of these FLCs, primarily Igκ, is associated with various disorders, including light-chain deposition disease, multiple myeloma, rheumatoid arthritis, diabetic nephropathy, and systemic lupus erythematosus (SLE).{55225,55232,53885} Cayman's Igκ Light Chain (mouse) Monoclonal Antibody (Clone RM103) can be used for ELISA and Western blot (WB) applications. The antibody recognizes non-reduced and reduced Igκ light chain from mouse samples at approximately 159 and 25 kDa, respectively.
宿主来源:
Rabbit
实验应用:
ELISA, WB
同种型:
IgG
免疫原:
Mouse IgG
克隆号:
RM103
保存温度:
-20
运输温度:
-20
产品形式:
100 µg of protein A-affinity purified monoclonal antibody
有效期:
365
上一个:Igλ Light Chain (mouse) Rabbit Monoclonal Antibody (Clone RM110)
下一个:IgG (mouse) Rabbit Monoclonal Antibody (Clone RM104)
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