官网链接
折扣/货期| 货号：19824 | 规格：100 µg | 目录价：￥5600 |
产品详情
产品名称:
Histone H3 Monoclonal Antibody (Clone 2B8)
别名:
H3
产品描述:
Histone H3 is a nuclear protein and a component of the nucleosome core, a basic unit of chromatin, that is essential for organizing genomic DNA in eukaryotic nuclei.{57056} It is a globular protein that contains an unstructured N-terminal tail that extends outside of the nucleosome core and is subject to various post-translational modifications (PTMs), including methylation, phosphorylation, acetylation, and citrullination.{57056,53978} Histone H3 PTMs function as epigenetic regulators of gene transcription by affecting chromatin structure and providing binding sites for many transcription factors, thus regulating several cellular functions including gene expression, cell cycle, and DNA replication and repair.{57056,56203} Differential methylation of histone H3 at various lysine residues is catalyzed by SET domain-containing methyltransferases and marks sites of transcriptional activation or repression.{57056} Citrullination of histone H3 by protein arginine deiminase 4 (PAD4; Item Nos. 10500 | 25915 | 28910) or PAD2 (Item No. 10785) induces the release of neutrophil extracellular traps (NETs), a network of decondensed DNA and intracellular proteins secreted by neutrophils as a pathogen defense mechanism.{52711,52712} Histone H3 mutations have been found in patients with diffuse intrinsic pontine glioma, leukemia, or chondroblastoma.{52713,49724} Cayman's Histone H3 Monoclonal Antibody (Clone 2B8) can be used for ELISA and Western blot (WB) applications. The antibody recognizes histone H3 at 17 kDa from human samples.
宿主来源:
Mouse
实验应用:
ELISA, WB
同种型:
IgG2a
免疫原:
Recombinant Histone H3 protein
克隆号:
2B8
保存温度:
-20
运输温度:
-20
产品形式:
100 µg of protein G-purified IgG
有效期:
1095
上一个:PAD2 Monoclonal Antibody (Clone 9F7)
下一个:DNA/RNA Oxidative Damage Monoclonal Antibody (Clone 7E6)
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