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折扣/货期| 货号：28622 | 规格：100 µg | 目录价：￥7630 |
产品详情
产品名称:
Citrullinated GFAP (human, recombinant)
别名:
ALXDRD|Glial Fibrillary Acidic Protein, Intermediate Filament Protein
产品描述:
Citrullinated glial fibrillary acidic protein (citGFAP) is a citrullinated form of GFAP (Item No. 27353), a class III intermediate filament (IF) protein that is expressed in mature astrocytes and contributes to cytoskeletal structure and strength.{53009} GFAP can be citrullinated in a calcium-dependent manner on the arginine residue at position 270 (R270) and at R416 by protein arginine deiminase 1 (PAD1; Item No. 10784) and PAD2 (Item No. 10785).{53021} citGFAP levels are increased by the calcium ionophore ionomycin (Item No. 10004974) in an in vitro model of traumatic brain injury (TBI) using NHA CC-2565 human astrocytes and are induced by controlled cortical impact in the cerebral cortex in a rat model of TBI.{53020} It has been found in the hippocampus in a rat model of Alzheimer's disease induced by amyloid-β (25-35), as well as in the retina in a mouse model of alkali-induced eye injury.{45561,45562} citGFAP has also been found in postmortem hippocampus from patients with Alzheimer's disease, and citGFAP levels are increased in postmortem-derived brain lesions from patients with multiple sclerosis.{53021,35771} Cayman's Citrullinated GFAP protein can be used for Western blot and ELISA applications.
保存温度:
-80
运输温度:
-80
产品形式:
10 mM Tris, pH 7.4
有效期:
365
纯度:
≥85% estimated by SDS-PAGE
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