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折扣/货期| 货号：28379-1 mg | 规格：1 mg | 目录价：￥44802 |
| 货号：28379-100 µg | 规格：100 µg | 目录价：￥7614 |
产品详情
产品名称:
PD-L2 Extracellular Domain (human, recombinant)
别名:
B7-DC|CD273|PDCD1 Ligand 2|Programmed Cell Death 1 Ligand 2
产品描述:
Programmed cell death 1 ligand 2 (PD-L2), also known as B7-DC and CD273, is a B7 family protein that is involved in regulation and attenuation of the adaptive immune response.{53686,52533} It is a 273-amino acid type I transmembrane protein encoded by the PDCD1LG2 gene in humans and is comprised of a 221-amino acid extracellular domain consisting of a signal peptide, an IgV-like domain, and an IgC-like domain, a transmembrane domain, and a cytoplasmic domain.{56030,53692} PD-L2 is expressed in dendritic cells and macrophages and is induced by IL-4 and IFN-γ.{53686} Binding of PD-L2 to its receptor, programmed cell death protein 1 (PD-1), suppresses T cell proliferation and cytokine production.{52533} PD-L2 is also expressed in a variety of tumor types, and elevated expression of PD-L2 in tumor tissue is associated with decreased overall survival in patients with hepatocellular carcinoma.{56031,56032} Cayman's PD-L2 Extracellular Domain (human, recombinant) protein can be used for ELISA and binding assay applications. This protein consists of 211 amino acids, has a calculated molecular weight of 24 kDa, an a predicted N-terminus of Leu20 after signal peptide cleavage. By SDS-PAGE, under reducing conditions, the apparent molecular mass of the protein is 40 to 45 kDa due to glycosylation.
保存温度:
-80
运输温度:
-80
产品形式:
Lyophilized from sterile PBS, pH 7.4
有效期:
365
纯度:
≥98% estimated by SDS-PAGE
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