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CD4 Monoclonal Antibody (Clone RIV7)

品牌：Cayman

官网链接

说明书

折扣/货期

货号：10004599

规格：1 ea (100 µg)

目录价：￥4410

产品详情

产品名称:

CD4 Monoclonal Antibody (Clone RIV7)

别名:

Cell Surface Glycoprotein CD4|Cluster of Differentiation 4|T Cell Surface Antigen T4

产品描述:

CD4 is a type I transmembrane glycoprotein that functions as a T cell receptor (TCR) co-receptor.{59673} It exists as a single polypeptide chain composed of four extracellular immunoglobulin-like (Ig-like) domains that interact with MHC class II molecules, a transmembrane domain, and a cytoplasmic tail that associates with the tyrosine kinase LCK and mediates signal transduction to the TCR, which is essential for T cell activation.{59674} It is expressed on the surface of, and used as a marker for, T cells, and its expression is used to characterize the development stage of thymocytes. Upon binding to antigen-displaying MHC class II molecules expressed by antigen-presenting cells (APCs), naïve CD4+ T cells differentiate and proliferate in a cytokine-dependent manner into a variety of T helper (Th) cell subsets, including Th1, Th2, and Th17 cells, which enhance and direct innate and adaptive immune cell responses to numerous pathogens and have additional roles in cancer, asthma and allergy, and autoimmunity.{59675,59676} CD4 is also the receptor for HIV attachment and entry into cells, resulting in depletion of CD4+ cells in patients infected with HIV.{59677,59678} Cayman's CD4 Monoclonal Antibody (Clone RVI7) can be used for flow cytometry (FC), immunocytochemistry (ICC), and immunohistochemistry (IHC) applications.

宿主来源:

Mouse

实验应用:

FC, ICC, IHC (frozen)

同种型:

IgG2a

免疫原:

Human peripheral lymphocytes

克隆号:

RIV7

保存温度:

-20