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Calcineurin A α Isoform (human, recombinant)
品牌：Cayman
货号：34630 规格：50 µg 目录价：￥5904
产品详情
产品名称:
Calcineurin A α Isoform (human, recombinant)
别名:
Calmodulin-dependent Calcineurin A Subunit α Isoform|CALNA1|CAM-PRP Catalytic Subunit|CCN1|CNA1|PPP2B|PPP3CA|Protein Phosphatase 2B|Serine/threonine-Protein Phosphatase 2B Catalytic Subunit α Isoform
产品描述:
Calcineurin A is the catalytic subunit of calcineurin, a serine/threonine phosphatase with roles in T cell activation, cardiac function, learning and memory, apoptosis, and cell cycle regulation.{61745,61746} Calcineurin A has three isoforms, α, β, and γ, which are encoded by PPP3CA, PPP3CB, and PPP3CC, respectively. Calcineurin A α is composed of an N-terminal catalytical domain, binding regions for the regulatory subunit calcineurin B (Item No. 34631) and the binding partner calmodulin, and a C-terminal autoinhibitory domain.{60846,60847} It is ubiquitously expressed and associates with calcineurin B and calmodulin in a calcium-dependent manner.{60848,60849} Calcineurin A α has roles in kidney development and function, as well as Tau dephosphorylation, but is dispensable for T cell development.{60849} Calcineurin A α-null mice exhibit impaired kidney function, failure to thrive, and shortened lifespan. Brain calcineurin A α levels are inversely correlated with disease severity in patients with Alzheimer's disease.{60850} Cayman's Calcineurin A α Isoform (human, recombinant) protein can be used for binding assays. This protein consists of 538 amino acids and has a calculated molecular weight of 60.8 kDa.
保存温度:
-80
运输温度:
-80
产品形式:
Lyophilized from sterile 20 mM Tris, pH 8.0, with 500 mM sodium chloride and 10% glycerol
有效期:
365
纯度:
≥94% estimated by SDS-PAGE
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