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折扣/货期| 货号：34486 | 规格：100 µg | 目录价：￥6720 |
产品详情
产品名称:
15-hydroxy Prostaglandin Dehydrogenase D50H variant (human, recombinant)
别名:
NAD+-dependent 15-hydroxy Prostaglandin Dehydrogenase|Prostaglandin Dehydrogenase 1|Short-chain Dehydrogenase/Reductase Family 36C Member 1
产品描述:
15-hydroxy Prostaglandin dehydrogenase (PGDH) is an enzyme of the short-chain alcohol dehydrogenase family that catalyzes the oxidation of prostaglandins to 15-keto metabolites with reduced biological activity.{8277,5201,340,55499} It uses NAD+ as a cofactor and, in addition to PGs, also converts various hydroxy fatty acids, such as HETEs, resolvins, and lipoxins, to less active keto metabolites.{55499,6339,15718,55500,55501} 15-PGDH acts as a tumor suppressor, and restoring HPGD, the gene encoding 15-PGDH, expression in human colon cancer cells in vitro reduces subsequent tumor formation in mouse xenograft models.{14568,14566,12480,18885} Knockout of Hpgd or inhibition of 15-PGDH in mice increases hepatic tissue regeneration and induces resistance to ulcerative colitis.{29053} Inhibition of 15-PGDH also increases mitochondrial function and autophagic flux in muscle tissue, as well as increases muscle mass and strength in aged mice.{59739} Cayman’s 15-PGDH D50H variant (human, recombinant) protein contains an aspartate-to-histidine substitution at position 50 (D50H) and can be used for enzyme assay and Western blot (WB) applications.
保存温度:
-80
运输温度:
-80
产品形式:
50 mM potassium phosphate, pH 7.6, with 150 mM sodium chloride, 1 mM EDTA, 0.1 mM DTT, and 5% glycerol
有效期:
365
纯度:
≥90% estimated by SDS-PAGE
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