APP (C99 Fragment) Monoclonal Antibody (Clone 8G4)-单抗-ELISA_抗体_蛋白_核苷酸

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APP (C99 Fragment) Monoclonal Antibody (Clone 8G4)

品牌：Cayman

官网链接

说明书

折扣/货期

货号：28636

规格：100 µg

目录价：￥5544

产品详情

产品名称:

APP (C99 Fragment) Monoclonal Antibody (Clone 8G4)

别名:

产品描述:

Amyloid precursor protein (APP) is a type I transmembrane protein that has a central role in the pathogenesis of Alzheimer’s disease, as well as additional roles in brain development, neuronal plasticity, and memory.{59228} APP is cleaved by β-secretase (BACE) in neuronal endosomes during amyloidogenic processing of APP, generating the C-terminal C99 fragment, which is localized to the endoplasmic membrane.{59223,59224} C99 is further cleaved by γ-secretase, liberating the APP intracellular domain (AICD) and generating amyloid-β (Aβ) peptides of various lengths, including Aβ40 (Item No. 21617) and Aβ42 (Item No. 20574), which are hallmarks of Alzheimer's disease. APP can also be cleaved by α-secretase during non-amyloidogenic processing of APP, which occurs at the neuronal plasma membrane and generates the neuroprotective soluble APP fragment sAPPα, as well as a variety of other fragments, including the C47 fragment.{59228,59226} Transgenic mice expressing mutant forms of APP exhibit extracellular Aβ deposits in the brain, as well as cognitive dysfunction, and are widely used models of Alzheimer’s disease.{59227} Intraneuronal C99 levels are increased in the transgenic APPE693Q mouse model of Alzheimer’s disease, as well as postmortem frontal cortex from patients with sporadic Alzheimer's disease.{59224,59225} Cayman's APP (C99 Fragment) Monoclonal Antibody (Clone 8G4) can be used for ELISA and immunohistochemistry (IHC) applications. The antibody recognizes the C-terminal region corresponding to the C99 fragment to detect intact APP, as well as the C47 APP fragment.

宿主来源:

Mouse

实验应用:

ELISA and IHC

同种型:

IgG2a

免疫原:

Peptide corresponding to the C99 fragment of human APP

克隆号:

8G4

保存温度:

-20