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    Amyloid-β Monoclonal Antibody (Clone 6C3, MOAB-2)
    货号：11610 规格：200 µg 目录价：￥4760
    产品详情
    产品名称:
    Amyloid-β Monoclonal Antibody (Clone 6C3, MOAB-2)
    别名:
    Aβ
    产品描述:
    Amyloid plaques composed primarily of the 42 amino acid form of amyloid-β peptide (Aβ42) are a hallmark of Alzheimer’s disease (AD). However, the roles of the various amyloid β peptide(s), especially Aβ42, related to the neurotoxicity characteristic of AD remains unclear. A major hindrance to evalsuating the role of Aβ in AD pathology has been the availability of anti-Aβ antibodies to selectively detect Aβ versus amyloid precursor protein (APP), Aβ40 versus Aβ42, and specific conformations of the peptide, particularly oligomeric forms. MOAB-2 (mouse IgG2b) is a pan-specific antibody specific to Aβ (residues 1-4) that differentiates intracellular Aβ from APP. MOAB-2 does not detect APP in cell culture media/lysates or in brain homogenates from transgenic mice expressing 5 familial AD mutation (5xFAD mice). Intraneuronal Aβ was confirmed by co-localization of MOAB-2 immunoreactivity with C-terminal antibodies specific for Aβ40 and Aβ42, and with cathepsin-D, a lysosomal marker. Additionally, MOAB-2 demonstrates strong intraneuronal and extra-cellular immunoreactivity in 5xFAD and 3xTg mouse brain tissues.{20683}
    宿主来源:
    Mouse
    实验应用:
    ELISA, WB
    同种型:
    IgG2b
    免疫原:
    Oligomeric form of amyloid-β peptide (Aβ42)
    克隆号:
    6C3
    保存温度:
    -20
    运输温度:
    -20
    产品形式:
    200 µg of protein G-purified antibody
    有效期:
    1095
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