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ACE2 (human) Monoclonal Antibody (Clone 8G5)
货号：31359 规格：100 µg 目录价：￥4410
产品详情
产品名称:
ACE2 (human) Monoclonal Antibody (Clone 8G5)
别名:
ACEH|ACE-related Carboxypeptidase|Angiotensin-converting Enzyme 2|Angiotensin-converting Enzyme Homolog|Metalloprotease MPROT15
产品描述:
Angiotensin-converting enzyme 2 (ACE2) is a carboxypeptidase and homolog of ACE1 that is encoded by ACE2 in humans.{53456,53457} It is a type I transmembrane protein composed of a cytoplasmic tail and an extracellular domain containing an HEMGH motif, characteristic of zinc-metallopeptidases, which exhibits carboxymonopeptidase activity.{53456} ACE2 is expressed in vascular endothelial cells where it catalyzes the conversion of angiotensin II to the vasodilatory peptide angiotensin 1-7 to regulate systemic blood pressure and angiotensin I to angiotensin 1-9, a peptide that counter-regulates the function of angiotensin II.{53456,53457,55475} It is also expressed in the epithelial cells of the kidney, heart, lung, small intestine, and liver and has roles in fluid homeostasis, cardiac contractility, and amino acid absorption, as well as the prevention of pulmonary fibrosis and hypertension. ACE2 also acts as a functional receptor for severe acute respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2 to facilitate viral entry into host cells.{49542,53458} Cayman’s ACE2 (human) Monoclonal Antibody (Clone 8G5) can be used for ELISA and Western blot (WB). The antibody recognizes ACE2 at approximately 92 kDa from human and mouse samples.
宿主来源:
Mouse
实验应用:
ELISA, WB
同种型:
IgG2b
免疫原:
Recombinant human ACE2
克隆号:
8G5
保存温度:
-20
运输温度:
-20
产品形式:
100 µg of protein G-purified monoclonal antibody
有效期:
1095
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