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折扣/货期| 货号：CDX-M0007-G025 | 规格：25 g | 目录价：￥546 |
| 货号：CDX-M0007-G100 | 规格：100 g | 目录价：￥1148 |
产品详情
产品名称:
4-Methylumbelliferone
别名:
beta-Methylumbelliferone; 4-MU; 7-Hydroxy-4-methylcoumarin; 7-Hydroxy-4-methyl-2H-1-benzopyran-2-one; 7-Hydroxy-4-methyl-2-chromenone; NSC 19026; NSC 9408; Omega 127; Pilot 447
产品描述:
4-Methylumbelliferone (4-MU) is a selective inhibitor of hyaluronan (HA) by depletion of UDP-glucuronic acid, the common substrate for HA synthesis and downregulation of hyaluronan synthase 2 and 3, MMP2 and MMP9. Since hyaluronan (HA) is a major component of the extracellular matrix that is synthesized in excess in cancer tissues, 4-MU has been shown to have anti-cancer activity and is involved in angiogenesis, invasion and metastasis of cancer. Fluorescent pH indicator, that is highly fluorescent in alkaline solution. Exhibits a blue fluorescence at pH7. The fluorescence intensity is pH dependent and increases to a maximum at pH10 (plateau above pH10). The fluorescence at pH10.3 is approximately 100 times as intense as at pH7. Spectral data: lambdaex=360nm; lambdaem=448nm; pH > 9. 4-Methylumbelliferone is an indicator also used in the determination of nitric acid and in 4-MU-O-substrates for the kinetic investigation of enzyme activity.
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
176.17
产品形式:
solid
有效期:
Stable for at least 2 years after receipt when stored at +4°C.
产地:
瑞士
纯度:
>95% (NMR)
CAS号:
90-33-5
分子式:
C10H8O3
溶解度:
Soluble in DMSO (20mg/ml), ethanol (20mg/ml) or methanol (20mg/ml). Insoluble in water.
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