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折扣/货期| 货号：12720-1 mg | 规格：1 mg | 目录价：￥1848 |
| 货号：12720-500 µg | 规格：500 µg | 目录价：￥1092 |
产品详情
产品名称:
15(R)-15-methyl Prostaglandin D2
别名:
15(R)-15-methyl PGD2
产品描述:
15(R)-15-methyl Prostaglandin D2 (15(R)-15-methyl PGD2) is a metabolically stable synthetic analog of PGD2 (Item No. 12010). The physiological actions of PGD2 include regulation of sleep, lowering of body temperature, inhibition of platelet aggregation and relaxation of vascular smooth muscle.{328,1185,580} PGD2 mediates its effects by 2 distinct G-protein-coupled receptors, DP1and CRTH2/DP2.{3128,10722,9769} 15(R)-15-methyl PGD2 is a potent, selective agonist for the CRTH2/DP2 receptor.{10723} The EC50 values for eosinophil CD11b expression, actin polymerization, and chemotaxis are 1.4, 3.8, and 1.7 nM, respectively, each of which is approximately 3-5 fold lower than those for PGD2. In contrast the EC50 for the DP1-mediated increase in platelet cAMP by 15(R)-15-methyl PGD2 is >10 µM.{10723}
保存温度:
-20
运输温度:
-20
预期分子量:
366.5
产品形式:
A solution in methyl acetate
有效期:
730
纯度:
≥95%
CAS号:
210978-26-0
分子式:
C21H34O5
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