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折扣/货期| 货号：19343 | 规格：100 µg | 目录价：￥4914 |
产品详情
产品名称:
15-deoxy-Δ12,14-Prostaglandin D2-d4
别名:
15-deoxy-Δ12,14-PGD2-d4
产品描述:
15-deoxy-Δ12,14-Prostaglandin D2-d4 (15-deoxy-Δ12,14-PGD2-d4) is an internal standard for the quantification of 15-deoxy-Δ12,14-PGD2 (Item No. 12700) by GC- or LC-MS. 15-deoxy-Δ12,14-PGD2 is a metabolite of PGD2 (Item No. 12010).{11797} It is an agonist of PGD2 receptor 2 (DP2) that binds DP2 (Ki = 50 nM for the mouse receptor expressed in HEK293 cell membranes) and induces activation of eosinophils (EC50 = 8 nM).{11399,11055} It also stimulates the recruitment of steroid receptor coactivator-1 (SRC-1) to peroxisome proliferator-activated receptor γ (PPARγ) and induces PPARγ-mediated transcription in a reporter assay when used at a concentration of 5 µM.{11797} 15-deoxy-Δ12,14-PGD2 is cytotoxic to L1210 murine leukemia cells (IC50 = 0.3 µg/ml).{1424} It inhibits ADP-induced platelet aggregation (IC50 = 320 ng/ml) less potently than PGD2.{1139}
保存温度:
-20
运输温度:
-20
预期分子量:
338.5
产品形式:
A solution in methyl acetate
有效期:
730
纯度:
≥99% deuterated forms (d1-d4)
CAS号:
2750534-91-7
分子式:
C20H26D4O4
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