Fas配体(FasL)也称为CD178，CD95配体或TNFSF6，是一种大小为40kDa的Ⅱ型跨膜糖蛋白，属于TNF超家族的成员。FasL在活化的T细胞以及脾脏、睾丸和眼睛中表达。当它与受体CD95（Fas）结合时，FasL诱导凋亡细胞死亡以维持外周耐受性。有些肿瘤过度表达FasL并诱导浸润淋巴细胞凋亡，使肿瘤逃避免疫反应的影响。CD178/CD95的相互作用也被认为在CD8+细胞增殖和中性粒细胞外渗、趋化和存活中起作用。据报道，MFL3抗体可阻断CD178/CD95诱导的细胞凋亡。
产品信息：
| 产品货号 | BE0319 |
| 产品名称 | InVivoMAb anti-mouse FasL (CD178) |
| 规格 | 1mg,5mg,25mg, 50mg, 100mg |
| 克隆号 | MFL3 |
| 同种型(Isotype) | Armenian Hamster IgG |
| 免疫原(Immunogen) | BHK cells expressing B6 mouse FasL |
| 成分(Formulation) | PBS, pH 7.0 |
| Contains no stabilizers or preservatives |
| 内毒素(Endotoxin) | <2EU/mg (<0.002EU/μg) |
| Determined by LAL gel clotting assay |
| 纯度(Purity) | >95% |
| Determined by SDS-PAGE |
| 无菌(Sterility) | 0.2 μM filtered |
| 生产(Production) | Purified from tissue culture supernatant in an animal free facility |
| 纯化(Purification) | Protein A |
| 保存(Storage) | Undiluted at 4°C in the dark |
| 应用(Reported Applications) | in vivo FasL blockade |
| In vitro FasL blockade |
| Functional assay |
| Immunohistochemistry (paraffin) |
| Flow Cytometry |
Application References:
Lakins, M. A., et al. (2018). 'Cancer-associated fibroblasts induce antigen-specific deletion of CD8 (+) T Cells to protect tumour cells.' Nat Commun 9(1): 948. PubMed
Lotti, R., et al. (2018). 'Soluble Fas Ligand Is Essential for Blister Formation in Pemphigus.' Front Immunol 9: 370. PubMed
Bien, K., et al. (2017). 'Involvement of Fas/FasL pathway in the murine model of atopic dermatitis.' Inflamm Res 66(8): 679-690. PubMed
D'Aloia, M. M., et al. (2016). 'T lymphocytes engineered to express a CD16-chimeric antigen receptor redirect T-cell immune responses against immunoglobulin G-opsonized target cells.' Cytotherapy 18(2): 278-290. PubMed
Linkermann, A., et al. (2011). 'Renal tubular Fas ligand mediates fratricide in cisplatin-induced acute kidney failure.' Kidney Int 79(2): 169-178. PubMed
Kayagaki, N., et al. (1997). 'Polymorphism of murine Fas ligand that affects the biological activity.' Proc Natl Acad Sci U S A 94(8): 3914-3919. PubMed
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| BE0091 | InVivoMAb polyclonal Armenian hamster IgG | 1mg,5mg,25mg,50mg, 100mg | 同型对照 |
| IP0070 | InVivoPure pH 7.0 Dilution Buffer | 50ml | 抗体稀释液 |
更多产品详情，请点击：https://bxcell.com/product/invivomab-anti-mouse-fasl-cd178/
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