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BioXcell新品推荐——InVivoMAb anti-mouse CD172a (SIRPα)单克隆抗体

2021-04-29
浏览次数: 37

研发背景:

P84单克隆抗体,也被称为CD172a抗体,可与信号调节蛋白α(SIRPα)反应。SIRPα蛋白是I型跨膜糖蛋白,在单核细胞、巨噬细胞和树突细胞均有表达。此外,在神经元和中枢神经系统的一些其他组织也发现有SIRPα蛋白的表达。其配体CD47在多种细胞均有表达。

 

SIRPαCD47参与调节树突细胞介导的T细胞活化、中性粒细胞迁移和吞噬等过程。SIRPα蛋白可在巨噬细胞的细胞膜上进行横向扩散并在吞噬性突触中积累,与CD47结合后,抑制巨噬细胞的吞噬作用。

 

研究结果表明,使用anti-SIRPα抗体阻断SIRPαCD47相互作用,可抑制小鼠体内肿瘤形成。此外,P84CD172a)单克隆抗体在体内和体外具有中和活性。

 

BioXcell最新推出InVivoMAb anti-mouse CD172a (SIRPα)单克隆抗体,助力肿瘤免疫检查点研究。



产品信息:

产品货号 BE0322
产品名称 InVivoMAb anti-mouse CD172a (SIRPα)
规格 1mg,5mg,25mg, 50mg, 100mg
克隆号 P84
同种型(Isotype) Rat IgG1, κ
免疫原(Immunogen) Mouse brain membrane protein
成分(Formulation) PBS, pH 7.0  
Contains no stabilizers or preservatives
内毒素(Endotoxin) <2EU/mg (<0.002EU/μg)
Determined by LAL gel clotting assay
纯度(Purity) >95%
Determined by SDS-PAGE
无菌(Sterility) 0.2 μM filtered
生产(Production) Purified from tissue culture supernatant in an animal free facility
纯化(Purification) Protein A
保存(Storage) Undiluted at 4°C in the dark
应用(Reported Applications) In vivo SIRPα blocking
In vitro SIRPα blocking
Western blot


Application References:

Yanagita, T., et al. (2017). 'Anti-SIRPalpha antibodies as a potential new tool for cancer immunotherapy.' JCI Insight 2(1): e89140. 

Koskinen, C., et al. (2013). 'Lack of CD47 impairs bone cell differentiation and results in an osteopenic phenotype in vivo due to impaired signal regulatory protein alpha (SIRPalpha) signaling.' J Biol Chem 288(41): 29333-29344. 

Teraoka, Y., et al. (2013). 'Expression of recipient CD47 on rat insulinoma cell xenografts prevents macrophage-mediated rejection through SIRPalpha inhibitory signaling in mice.' PLoS One 8(3): e58359. 

Zen, K., et al. (2013). 'Inflammation-induced proteolytic processing of the SIRPalpha cytoplasmic ITIM in neutrophils propagates a proinflammatory state.' Nat Commun 4: 2436.

Lundberg, P., et al. (2007). 'Osteoclast formation is strongly reduced both in vivo and in vitro in the absence of CD47/SIRPalpha-interaction.' Biochem Biophys Res Commun 352(2): 444-448. 

Oldenborg, P. A., et al. (2001). 'CD47-signal regulatory protein alpha (SIRPalpha) regulates Fcgamma and complement receptor-mediated phagocytosis.' J Exp Med 193(7): 855-862.

 

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