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    BioXCell热销产品--RecombiMAb anti-mouse VEGFR-2

    2023-10-10
    浏览次数: 36

    BioXCell热销产品--RecombiMAb anti-mouse VEGFR-2

     

    产品描述:

    DC101-CP132单克隆抗体是原始DC101单克隆的重组嵌合型抗体。可变结构域序列与原始DC101相同,但是恒定区序列已经从大鼠IgG1变为小鼠IgG2a。DC101-CP132单克隆抗体像原始大鼠IgG1抗体一样,不包含Fc突变。

     

    DC101-CP132单克隆抗体能与小鼠VEGFR-2(血管内皮生长因子受体2)反应,VEGFR-2也称为CD309、KDR和Flk-1。VEGFR-2是酪氨酸蛋白激酶家族的成员。当结合到其配体血管内皮生长因子时发挥生理作用,血管内皮生长因子受体-2在血管发育和通透性中起关键作用。血管内皮生长因子受体-2在成人心脏、肺、肾、脑和骨骼肌的内皮细胞中高表达,在其他组织中低表达。DC101单克隆抗体已被证明在体内抑制VEGFR-2信号传导。

    BioXCell热销产品--RecombiMAb anti-mouse VEGFR-2

     

    产品详情:

    产品名称

    RecombiMAb anti-mouse VEGFR-2

    产品货号

    CP132

    产品规格

    1/5/25/50/100mg

    反应种属

    Mouse

    克隆号

    DC101-CP132

    同种型

    Mouse IgG2a(switched from rat IgG1)

    免疫原

    Mouse VEGFR-2-SEAPs soluble receptor

    实验应用

    in vivo blocking of VEGF/VEGFR-2 signaling*
    in vitro blocking of VEGFR signaling*
    Western blot*
    *Reported for the original rat IgG1 DC101 antibody

    产品形式

    PBS, pH 7.0,Contains no stabilizers or preservatives

    纯度

    >95%, Determined by SDS-PAGE

    聚合

    <5%, Determined by SEC

    无菌处理

    0.2 µm filtration

    纯化方式

    Protein G

    分子量

    150 kDa

    小鼠病原检测

    Ectromelia/Mousepox Virus: Negative

    Hantavirus: Negative

    K Virus: Negative

    Lactate Dehydrogenase-Elevating Virus: Negative

    Lymphocytic Choriomeningitis virus: Negative

    Mouse Adenovirus: Negative

    Mouse Cytomegalovirus: Negative

    Mouse Hepatitis Virus: Negative

    Mouse Minute Virus: Negative

    Mouse Norovirus: Negative

    Mouse Parvovirus: Negative

    Mouse Rotavirus: Negative

    Mycoplasma Pulmonis: Negative

    Pneumonia Virus of Mice: Negative

    Polyoma Virus: Negative

    Reovirus Screen: Negative

    Sendai Virus: Negative

    Theiler’s Murine Encephalomyelitis: Negative

    保存条件

    抗体原液保存在4°C,不能冷冻保存。

    推荐同型对照

    InVivoPlus mouse IgG2a isotype control, unknown specificity(货号BP0085)

    推荐抗体稀释液

    InVivoPure pH 7.0 Dilution Buffer(货号IP0070)

     

     

     

     

    该产品自上市已被多篇SCI文献引用,品质有保证,以下是部分已发表的文献引用:

    应用

    文章

    体内VEGF/VEGFR-2信号阻断

    (in vivo blocking of VEGF/VEGFR-2 signaling)

    1. Ding, X., et al. (2015). 'Distinct functions of epidermal and myeloid-derived VEGF-A in skin tumorigenesis mediated by HPV8' Cancer Res 75(2): 330-343.

    2. Lee, H. J., et al. (2015). 'Inhibition of vascular endothelial growth factor A and hypoxia-inducible factor 1alpha maximizes the effects of radiation in sarcoma mouse models through destruction of tumor vasculature' Int J Radiat Oncol Biol Phys 91(3): 621-630.

    3. Arulanandam, R., et al. (2015). 'VEGF-Mediated Induction of PRD1-BF1/Blimp1 Expression Sensitizes Tumor Vasculature to Oncolytic Virus Infection' Cancer Cell 28(2): 210-224.

    4. Kizhatil, K., et al. (2014). 'Schlemm’s canal is a unique vessel with a combination of blood vascular and lymphatic phenotypes that forms by a novel developmental process' PLoS Biol 12(7): e1001912.

    体内VEGF/VEGFR-2信号阻断,体外VEGFR信号阻断

    (in vivo blocking of VEGF/VEGFR-2 signaling, in vitro blocking of VEGFR signaling)

    1.Larrayoz, M., et al. (2014). 'Contrasting responses of non-small cell lung cancer to antiangiogenic therapies depend on histological subtype' EMBO Mol Med 6(4): 539-550.  

     

     

    更多产品详情请咨询 BioXCell 中国授权代理——欣博盛生物

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