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    BioXCell热销产品--RecombiMAb anti-mouse CTLA-4 (CD152) (LALA-PG)

    2023-09-01
    浏览次数: 217

    BioXCell热销产品--RecombiMAb anti-mouse CTLA-4 (CD152) (LALA-PG)

     

    产品描述:

    9D9-CP008单克隆抗体是原始9D9单克隆抗体的重组嵌合型抗体。可变结构域序列与原始9D9克隆号相同,但是恒定区序列已经从小鼠IgG2b变为小鼠IgG2a。9D9-CP008单克隆抗体在Fc片段中也含有LALA-PG突变,使其无法与内源性Fcγ受体结合。

     

    9D9-CP008单克隆抗体能与小鼠CTLA-4(细胞毒性T淋巴细胞抗原-4)反应,CTLA-4也称为CD152。CTLA-4是一种33 kDa的细胞表面受体,由属于免疫球蛋白超家族CD28家族的Ctla4基因编码。CTLA-4在活化的T淋巴细胞和B淋巴细胞上表达。CTLA-4在结构上类似于T细胞共刺激蛋白CD28,两种分子都与B7家族成员B7-1 (CD80)和B7-2 (CD86)结合。在与配体结合时,CTLA-4负调节细胞介导的免疫反应。CTLA-4在诱导和/或维持免疫耐受、胸腺细胞发育和保护性免疫调节中起作用。CTLA-4在免疫下调中的关键作用已经在CTLA-4缺陷小鼠中得到证实,这些小鼠在3-5周龄时由于淋巴增生性疾病的发展而死亡。CTLA-4目前是肿瘤免疫治疗中的热门免疫检查点靶点之一。

     

    产品详情:

    产品名称

    RecombiMAb anti-mouse CTLA-4 (CD152) (LALA-PG)

    产品货号

    CP008

    产品规格

    1mg

    反应种属

    Mouse

    克隆号

    9D9-CP008

    同种型

    Mouse IgG2b(switched from mouse IgG2a)

    免疫原

    Not available or unknown

    实验应用

    in vivo CTLA-4 neutralization*

    Western blot*

    *Reported for the original mouse IgG2b 9D9 antibody

    产品形式

    PBS, pH 7.0,Contains no stabilizers or preservatives

    纯度

    >95%, Determined by SDS-PAGE

    聚合

    <5%, Determined by SEC

    无菌处理

    0.2 µm filtration

    纯化方式

    Protein A

    分子量

    150 kDa

    小鼠病原检测

    Ectromelia/Mousepox Virus: Negative

    Hantavirus: Negative

    K Virus: Negative

    Lactate Dehydrogenase-Elevating Virus: Negative

    Lymphocytic Choriomeningitis virus: Negative

    Mouse Adenovirus: Negative

    Mouse Cytomegalovirus: Negative

    Mouse Hepatitis Virus: Negative

    Mouse Minute Virus: Negative

    Mouse Norovirus: Negative

    Mouse Parvovirus: Negative

    Mouse Rotavirus: Negative

    Mycoplasma Pulmonis: Negative

    Pneumonia Virus of Mice: Negative

    Polyoma Virus: Negative

    Reovirus Screen: Negative

    Sendai Virus: Negative

    Theiler’s Murine Encephalomyelitis: Negative

    保存条件

    抗体原液保存在4°C,不能冷冻保存。

    推荐抗体稀释液

    InVivoPure pH 7.0 Dilution Buffer(货号IP0070)

     

    该产品自上市已被多篇SCI文献引用,品质有保证,以下是部分已发表的文献引用:

    应用

    文章

    体内CTLA-4中和

    (in vivo CTLA-4 

    neutralization)

    1. Dai, M., et al. (2015). 'Curing mice with large tumors by locally 

    delivering combinations of immunomodulatory antibodies' 

    Clin Cancer Res 21(5): 1127-1138.

    2. Zippelius, A., et al. (2015). 'Induced PD-L1 expression mediates 

    acquired resistance to agonistic anti-CD40 treatment' Cancer Immunol 

    Res 3(3): 236-244.

    3. Redmond, W. L., et al. (2014). 'Combined targeting of costimulatory 

    (OX40) and coinhibitory (CTLA-4) pathways elicits potent effector T 

    cells capable of driving robust antitumor immunity' Cancer Immunol 

    Res 2(2): 142-153.

    4. Condamine, T., et al. (2014). 'ER stress regulates myeloid-derived 

    suppressor cell fate through TRAIL-R-mediated apoptosis' J Clin Invest 

    124(6): 2626-2639.

    5. Muller, P., et al. (2014). 'Microtubule-depolymerizing agents used in 

    antibody-drug conjugates induce antitumor immunity by stimulation of 

    dendritic cells' Cancer Immunol Res 2(8): 741-755.

    6. Bulliard, Y., et al. (2013). 'Activating Fc gamma receptors contribute 

    to the antitumor activities of immunoregulatory receptor-targeting 

    antibodies' J Exp Med 210(9): 1685-1693.

     

     

     

    BioXCell热销产品--RecombiMAb anti-mouse CTLA-4 (CD152) (LALA-PG)

    更多产品详情请咨询 BioXCell 中国授权代理——欣博盛生物

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