CDS可识别受损的、定位错误的、或致病性DNA，进而通过TBK1-IRF3通路诱导I型干扰素的产生。DNA通常定位于细胞核或线粒体中，但当它的合成或运输出现错误时会在细胞浆中聚集。此外，在感染情况下，病毒或微生物的DNA也可以进入到宿主细胞的细胞浆中。许多CDS已经被报道，包括腺苷脱氨酶DAI、解旋酶DDX41、干扰素诱导的IF116蛋白，以及cGAS(环-GMP-AMP合成酶)。AIM2是另外一种胞浆脱氧核糖核酸传感器，它受到刺激后形成炎症小体并进一步诱导产生IL-1®。
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PRODUCT | ORIGIN/DESCRIPTION | GRADE* | WORKING CONCENTRATION | QTY | CATALOG CODE |
CDS Agonists |
ODN TTAGGG (A151) | Inhibitory ODN, human preferred | TLR2 -/ TLR4 - | 100 nM - 10 µM | 200 µg 1 mg | tlrl-ttag151 tlrl-ttag151-1 |
dsDNA-EC | E. coli K12 genomic DNA | TLR2 -/ TLR4 - | 30 ng - 1 µg/ml | 200 µg | tlrl-ecdna |
G3-YSD NEW | Y-form DNA | TLR2 -/ TLR4 - | 100 ng - 1 µg/ml | 200 µg | tlrl-ydna |
G3-YSD Control NEW | Control for Y-form DNA | TLR2 -/ TLR4 - | 100 ng - 1 µg/ml | 200 µg | tlrl-ydnac |
HSV-60 Naked | HSV1-derived 60 bp oligonucleotide | TLR2 -/ TLR4 - | 30 ng - 10 µg/ml | 200 µg | tlrl-hsv60n |
HSV-60 LyoVec™ | Precomplexed HSV1-derived 60 bp ODN | TLR2 -/ TLR4 - | 300 ng - 10 µg/ml | 100 µg | tlrl-hsv60c |
HSV-60c Naked | Control for HSV-60 ODN | TLR2 -/ TLR4 - | 30 ng - 10 µg/ml | 200 µg | tlrl-hsv60cn |
HSV-60c/LyoVec™ | Precomplexed control for HSV-60 ODN | TLR2 -/ TLR4 - | 300 ng - 10 µg/ml | 100 µg | tlrl-hsv60cc |
ISD Naked | Interferon stimulatory DNA | TLR2 -/ TLR4 - | 100 ng - 10 µg/ml | 200 µg | tlrl-isdn |
ISD/LyoVec™ | Precomplexed interferon stimulatory DNA | TLR2 -/ TLR4 - | 300 ng - 10 µg/ml | 100 µg | tlrl-isdc |
ISD Control Naked | Non-immunostimulatory ODN | TLR2 -/ TLR4 - | 100 ng - 10 µg/ml | 200 µg | tlrl-isdcn |
ISD Control/LyoVec™ | Precomplexed non-immunostimulatory ODN | TLR2 -/ TLR4 - | 300 ng - 10 µg/ml | 100 µg | tlrl-isdcc |
Poly(dA:dT) Naked | Poly(dA-dT)•poly(dT-dA) | TLR2 -/ TLR4 - | 1 - 5 µg/ml | 200 µg 1 mg | tlrl-patn tlrl-patn-1 |
Poly(dA:dT)/LyoVec™ | Poly(dA-dT)•poly(dT-dA)/LyoVec™ complexes | TLR2 -/ TLR4 - | 1 - 5 µg/ml | 100 µg | tlrl-patc |
Poly(dA:dT)/Rhodamine | Rhodamine labeled poly(dA-dT)•poly(dT-dA) | TLR2 -/ TLR4 - | 30 ng - 10 µg/ml | 10 µg | tlrl-patrh |
Poly(dG:dC) Naked | Poly(dG-dC)•poly(dG-dC) | TLR2 -/ TLR4 - | 10 ng - 10 µg/ml | 200 µg | tlrl-pgcn |
Poly(dG:dC)/LyoVec™ | Poly(dG-dC)•poly(dG-dC)/LyoVec™ complexes | TLR2 -/ TLR4 - | 10 ng - 10 µg/ml | 100 µg | tlrl-pgcc |
VACV-70 Naked | Vaccinia virus-derived 70 bp oligonucleotide | TLR2 -/ TLR4 - | 30 ng - 10 µg/ml | 200 µg | tlrl-vav70n |
VACV-70/LyoVec™ | Precomplexed vaccinia virus-derived 70 bp ODN | TLR2 -/ TLR4 - | 300 ng - 10 µg/ml | 100 µg | tlrl-vav70c |
VACV-70c Naked | Control for VACV-70 ODN | TLR2 -/ TLR4 - | 30 ng - 10 µg/ml | 200 µg | tlrl-vav70cn |
VACV-70c/LyoVec™ | Precomplexed control for VACV-70 ODN | TLR2 -/ TLR4 - | 300 ng - 10 µg/ml | 100 µg | tlrl-vav70cc |
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