Dectin-1是C型凝集素受体(CLR)家族成员之一，在抗真菌天然免疫反应中发挥重要作用。Dectin-1是β-glucan(β-葡聚糖)的特异性跨膜受体。β-glucan，即葡萄糖聚合物，则是真菌(包括酿酒酵母Saccharomyces cerevisiae和白色念珠球菌Candida albican)细胞壁的主要成分。与其受体结合后，Dectin-1会引起细胞胞吞作用，并通过Syk激酶和接头分子CARD9/Bcl10/Malt1传递信号，进而诱导活性氧ROS的产生、NF-κB的活化及后续炎症因子的产生。Dectin-1和TLR2可协同发挥作用来增强各自的信号级联反应。
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PRODUCT | ORIGIN/DESCRIPTION | GRADE* | WORKING CONCENTRATION | QTY | CATALOG CODE |
Dectin-1 Agonists |
Beta-Glucan Peptide | Beta-glucan from Trametes versicolor | TLR2 -/ TLR4 - | 1 - 100 µg/ml | 50 mg | tlrl-bgp |
Curdlan | Beta-1,3-glucan from Alcaligenes faecalis | TLR2 -/ TLR4 - | 100 µg/ml | 1 g | tlrl-curd |
HKCA | Heat-killed Candida albicans | TLR2 -/ TLR4 - | 108 cells/ml | 109 cells | tlrl-hkca |
Laminarin | Soluble beta-glucan from Laminaria digitata | TLR2 +/ TLR4 - | 1 - 100 µg/ml | 100 mg | tlrl-lam |
Pustulan | Beta-glucan from Lasallia pustulata | TLR2 -/ TLR4 - | 1 - 100 µg/ml | 100 mg | tlrl-pst |
Schizophyllan | Beta-glucan from Schizophyllum commune | TLR2 -/ TLR4 - | 1 - 100 µg/ml | 100 mg | tlrl-spg |
PRODUCT | ORIGIN/DESCRIPTION | GRADE* | WORKING CONCENTRATION | QTY | CATALOG CODE |
Dectin-1 Agonists |
Scleroglucan | Beta-glucan from Sclerotium rolfsii | TLR2 +/ TLR4 + | 1 - 100 µg/ml | 100 mg | tlrl-scg |
WGP Dispersible | Whole Glucan Particles, insoluble | TLR2 -/ TLR4 - | 1 - 200 µg/ml | 50 mg | tlrl-wgp |
WGP Soluble | Whole Glucan Particles, soluble | TLR2 -/ TLR4 - | 1 ng - 1 µg/ml | 50 mg | tlrl-wgps |
Zymosan | Cell wall preparation from S. cerevisiae | TLR2 +/ TLR4 - | 1 - 10 µg/ml | 100 mg | tlrl-zyn |
Zymosan Depleted | Hot alkali treated zymosan | TLR2 -/ TLR4 - | 100 µg/ml | 10 mg | tlrl-zyd |
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