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Clozapine N-oxide BML-NS105 (1)

2021-05-08
浏览次数: 51

Clozapine N-oxide  BML-NS105  

氯氮平主要代谢物

纯度≥99% (HPLC),适用于体内和体外实验。

外观:黄色固体

可溶性:可溶于水,溶解度为5mg/ml。

稳定性:液体-20度能够保持4个月。


参考文献:

Activation and inhibition of transient receptor potential TRPM3-induced gene transcription: A. Lesch, et al. ; Br. J. Pharmacol.171, 2645 (2014), Abstract;

Chemogenetic silencing of neurons in retrosplenial cortex disrupts sensory preconditioning: S. Robinson, et al.; J. Neurosci. 34, 10982 (2014), Abstract;

CREB Regulates Memory Allocations in the Insular Cortex: Y. Sano, et al.; Curr. Biol. 24, 2833 (2014), Abstract;

Cyclin-Dependent Kinase 5 in the Ventral Tegmental Area Regulates Depression-Related Behaviors: P. Zhong, et al.; J. Neurosci. 34, 6352 (2014), AbstractFull Text

Direct excitation of parvalbumin-positive interneurons by M1 muscarinic acetylcholine receptors: roles in cellular excitability, inhibitory transmission and cognition: F. Yi, et al.; J. Physiol. 592, 3463 (2014), Abstract;

Muscarinic excitation of parvalbumin-positive interneurons contributes to the severity of pilocarpine-induced seizures: F. Yi, et al.; Epilepsia (2014), Abstract;

Regulation of immediate-early gene transcription following activation of Gα(q)-coupled designer receptors: A. Kaufmann, et al.; J. Cell. Biochem. 114, 681 (2013), Abstract;

Developing chemical genetic approaches to explore G protein-coupled receptor function: validation of the use of a receptor activated solely by synthetic ligand (RASSL): E. Alvarez-Curto, et al.; Mol. Pharmacol. 80, 1033 (2011), AbstractFull Text

Small molecule inhibitors of the Candida albicans budded-to-hyphal transition act through multiple signaling pathways: J. Midkiff, et al.; PLoS One 6, e25395 (2011), AbstractFull Text

Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors: B.L. Roth, et al.; J. Pharmacol. Exp. Ther. 268, 1403 (1994), Abstract;

Decomposition of clozapine N-oxide in the qualitative and quantitative analysis of clozapine and its metabolites: G. Lin, etal.; J. Pharm. Sci. 83, 1412 (1994), Abstract;


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