高水平的血管生成与许多类型的癌症的不良预后有关,然而目前存在的抗血管生成疗法的疗效仍不令人满意,尤其是在延长TNBC(triple-negative breast cancer)患者的总生存期方面没有显著效果。研究发现肿瘤相关内皮细胞通过诱导凋亡限制抗肿瘤免疫,通过Fas配体(FasL)介导的机制浸润T淋巴细胞。最近,中国科学院上海药物研究所研究团队在期刊《Advanced Materials》(IF=29.4)上发表题为“Inhibiting Endothelial Cell‐Mediated T Lymphocyte Apoptosis with Integrin‐Targeting Peptide‐Drug Conjugate Filaments for Chemoimmunotherapy of Triple‐Negative Breast Cancer.”的文章,该研究团队设计了一种PDCs(peptide-drug conjugate),通过将7-乙基-10-羟基喜树碱(SN38)通过一个RGDR或HKD基序的亲水片段连接到在其C-末端谷胱甘肽反应接头,PDCs在水溶液中自发组装成细丝解决方案。含1% SN38-RGDR(SN38-HKD/RGDR)的PDC长丝有效靶向表达上调的三阴性乳腺癌(TNBC)细胞和TECs,并诱导肿瘤细胞的免疫原性细胞死亡(ICD)和FasL下调 TECs。SN38-HKD/RGDR增加CD8+ T细胞的浸润、活性和生存力, 从而抑制原发性肿瘤和肺转移瘤的生长。这项研究指出癌细胞和TECs与整合素靶向的协同调节 PDC细丝作为TNBC化学免疫疗法的一种有前途的策略。
本文中使用了欣博盛Mouse VEGF, IL-10, IFN-γ, TNF-α 和 IL-12p70 ELISA 检测了细胞培养液上清中目标蛋白的含量。
1.文章题目:Inhibiting Endothelial Cell‐Mediated T Lymphocyte Apoptosis with Integrin‐Targeting Peptide‐Drug Conjugate Filaments for Chemoimmunotherapy of Triple‐Negative Breast Cancer.
期 刊:Advanced Materials(影响因子:29.4)
发表时间:17 October 2023
作 者:Cai Y, Zhu B, Shan X, et al.
作者单位:中国科学院上海药物研究所
使用产品:Mouse VEGF, IL-10, IFN-γ, TNF-α and IL-12p70 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37847869/
2.文章题目:Myoglobin-loaded gadolinium nanotexaphyrins for oxygen synergy and imaging-guided radiosesensitization therapy.
期 刊:Nature Communications(影响因子:16.6)
发表时间:4 October 2023
作 者:Ma X, Liang X, Yao M, et al.
作者单位:中国科学院生物物理研究所
使用产品:Mouse IL-1β ELISA kit (Quick Test)
https://pubmed.ncbi.nlm.nih.gov/37794000/
3.文章题目:Psycho-biological effects with practicing Mano Shakti Yoga to Stressed College Students: A randomized controlled trial.
期 刊:Brain Behavior and Immunity Integrative(影响因子:15.1)
发表时间:6 October 2023
作 者:Pal R, Gao K, Li X, et al.
作者单位:电子科技大学
使用产品:Cortisol Saliva ELISA
https://www.sciencedirect.com/science/article/pii/S2949834123000284
4.文章题目:Resveratrol-loaded nanoplatform RSV@DTPF promote alveolar bone regeneration in OVX rat through remodeling bone-immune microenvironment.
期 刊:Chemical Engineering Journal(影响因子:15.1)
发表时间:18 October 2023
作 者:Haoran Peng , Xinyi Qiu , Mingyue Cheng et al.
作者单位:南京大学医学院
使用产品:Mouse TNF-α ELISA kit
https://www.sciencedirect.com/science/article/pii/S1385894723053469
5.文章题目:ALKBH5 mediates silica particles-induced pulmonary inflammation through increased m6A modification of Slamf7 and autophagy dysfunction.
期 刊:Journal of Hazardous Materials(影响因子:13.6)
发表时间:7 October 2023
作 者:Yin H, Gu P, Xie Y, et al.
作者单位:华中科技大学
使用产品:Mouse IL-6 and TNF-α ELISA kits
样本类型:肺泡灌洗液
https://pubmed.ncbi.nlm.nih.gov/37827106/
6.文章题目:Dimethyl fumarate ameliorates erectile dysfunction in bilateral cavernous nerve injury rats by inhibiting oxidative stress and NLRP3 inflammasome-mediated pyroptosis of nerve via activation of Nrf2/HO-1 signaling pathway.
期 刊:Redox Biology(影响因子:11.4)
发表时间:18 October 2023
作 者:Guoda Song, Jiaxin Wang, Jihong Liu et al.
作者单位:华中科技大学同济医学院
使用产品:Rat IL-18 ELISA kit
https://www.sciencedirect.com/science/article/pii/S2213231723003397
7.文章题目:Hybrid Mrna Nano Vaccine Potentiates Antigenic Peptide Presentation And Dendritic Cell Maturation for Effective Cancer Vaccine Therapy And Enhances Response to Immune Checkpoint Blockade.
期 刊:Advanced Healthcare Materials(影响因子:10)
发表时间:11 October 2023
作 者:Shi L, Yang J, Nie Y, et al.
作者单位:上海交通大学
使用产品:Mouse IFN-γ ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37822133/
8.文章题目:Ultra‐high static magnetic fields cause immunosuppression through disrupting B‐cell peripheral differentiation and negatively regulating BCR signaling.
期 刊:MedComm(影响因子:9.9)
发表时间:1 October 2023
作 者:Gu H, Fu Y, Yu B, et al.
作者单位:华中科技大学
使用产品:Mouse IgM ELISA kit
https://pubmed.ncbi.nlm.nih.gov/37789963/
9.文章题目:Gastric cancer derived exosomal THBS1 enhanced Vγ9Vδ2 T-cell function through activating RIG-I-like receptor signaling pathway in a N6-methyladenosine methylation dependent manne.
期 刊:Cancer Letters(影响因子:9.7)
发表时间:7 October 2023
作 者:Li J, Feng H, Zhu J, et al.
作者单位:苏州大学附属第一医院
使用产品:Human Perforin and Granzyme B ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37783390/
10.文章题目:Small molecule inhibition of TFF3 overcomes tamoxifen resistance and enhances taxane efficacy in ER+ mammary carcinoma.
期 刊:Cancer Letters(影响因子:9.7)
发表时间:17 October 2023
作 者:Hui Guo, Yan Qin Tan, Xiaoming Huang,et al
作者单位:清华大学伯克利深圳研究所
使用产品:Annexin VFITC/PI apoptosis assay kit
https://pubmed.ncbi.nlm.nih.gov/37858772/
11.文章题目:USP1 promotes cholangiocarcinoma progression by deubiquitinating PARP1 to prevent its proteasomal degradation.
期 刊:Cell Death & Disease(影响因子:9)
发表时间:11 October 2023
作 者:Zhang D Y, Zhu Y, Wu Q, et al.
作者单位:蚌埠医学院第一附属医院
使用产品:Annexin V-FITC/PI apoptosis assay kit
https://pubmed.ncbi.nlm.nih.gov/37821462/
12.文章题目:Diethylaminoethyl-dextran and monocyte cell membrane coated 1, 8-cineole delivery system for intracellular delivery and synergistic treatment of atherosclerosis.
期 刊:International Journal of Biological Macromolecules(影响因子:8.2)
发表时间:10 October 2023
作 者:Jiang F, Wu G, Yang H, et al.
作者单位:贵州医科大学
使用产品:Mouse IL-6 and IL-10 ELISA kits
样本类型:主动脉组织
https://pubmed.ncbi.nlm.nih.gov/37827418/
13.文章题目:Macrophage neogenin deficiency exacerbates myocardial remodeling and inflammation after acute myocardial infarction through JAK1-STAT1 signaling.
期 刊:Cellular and Molecular Life Sciences(影响因子:8)
发表时间:12 October 2023
作 者:Zhang J, Xu Y, Wei C, et al.
作者单位:武汉大学人民医院
使用产品:Mouse TNF-α and IL-1β ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37824022/
14.文章题目:Construction and evalsuation of Novel Dual-function Antifungal Inhibitors and Covalent Organic Framework Carriers Based on the Infection Microenvironment.
期 刊:Journal of Medicinal Chemistry(影响因子:7.3)
发表时间:12 October 2023
作 者:Liu Y, Wang Q, Yu S, et al.
作者单位:聊城大学
使用产品:Human PD-L1/B7−H1 ELISA kit
https://pubmed.ncbi.nlm.nih.gov/37752076/
15.文章题目:Integrating network analysis and experimental validation to reveal the mechanism of pinocembrin in alleviating high glucose and free fatty acid-induced lipid accumulation in HepG2 cells.
期 刊:Journal of Functional Foods(影响因子:5.6)
发表时间:31 October 2023
作 者:Kun Hu, Yongjin Sun, Jie Wang, et al.
作者单位:常州大学
使用产品:Human IL-1β and IL-6 ELISA kits
https://www.sciencedirect.com/science/article/pii/S1756464623004796
16.文章题目:Qi-Zhi-Wei-Tong granules alleviates chronic non-atrophic gastritis in mice by altering the gut microbiota and bile acid metabolism.
期 刊:Journal of Ethnopharmacology(影响因子:5.4)
发表时间:12 October 2023
作 者:Chen M, Li Y, Li L, et al.
作者单位:湖北中医药大学
使用产品:Mouse IL-1β and Rat IL-1β ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37838294/
17.文章题目:A comprehensive quality evalsuation for Huangqi Guizhi Wuwu decoction by integrating UPLC-DAD/MS chemical profile and pharmacodynamics combined with chemometric analysis.
期 刊:Journal of Ethnopharmacology(影响因子:5.4)
发表时间:16 October 2023
作 者:Jiang M, Yang L, Zou L, et al.
作者单位:澳门大学
使用产品:Mouse TNF-α and IL-6 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37852340/
18.文章题目:LIF Aggravates Pulpitis by Promoting Inflammatory Response in Macrophages.
期 刊:Inflammation(影响因子:5.1)
发表时间:2 October 2023
作 者:Guo D, Dong W, Cong Y, et al.
作者单位:武汉大学
使用产品:Mouse IL-6 and Human MCP-1 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37782452/
19.文章题目:METTL3 and METTL14 regulate IL-6 expression via RNA m6A modification of zinc transporter SLC39A9 and DNA methylation of IL-6 in periodontal ligament cells.
期 刊:Biochimica et Biophysica Acta (BBA)-Molecular Cell Research(影响因子:5.1)
发表时间:9 October 2023
作 者:Huang J, Wang Y, Zhou Y.
作者单位:武汉大学口腔医学院
使用产品:Human IL-6 ELISA kit
https://pubmed.ncbi.nlm.nih.gov/37821055/
20.文章题目:Polygonum Cuspidatum Alcohol Extract Exerts Analgesic Effects via the MAPK/ERK Signaling Pathway.
期 刊:Drug Design, Development and Therapy(影响因子:4.8)
发表时间:19 October 2023
作 者:Yan Lan, Yu-Kun Zheng, Liu-Yi et al.
作者单位:华中科技大学
使用产品:Mouse 1L-1β ELISA kit
https://pubmed.ncbi.nlm.nih.gov/37876500/
21.文章题目:Desmethoxycurcumin aids IFNα's anti-HBV activity by antagonizing CRYAB reduction and stabilizing IFNAR1 protein.
期 刊:Journal of Drug Targeting(影响因子:4.5)
发表时间:18 October 2023
作 者:Wei J, Deng X, Dai W, et al.
作者单位:重庆医科大学附属第一医院
使用产品:Human IFN-α and IFN-β ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37851377/
22.文章题目:Overexpression of Lias Gene Alleviates Cadmium-Induced Kidney Injury in Mice Involving Multiple Effects: Metabolism, Oxidative Stress, and Inflammation.
期 刊:Biological Trace Element Research(影响因子:3.9)
发表时间:7 October 2023
作 者:Xu G, Li W, Zhao Y, et al.
作者单位:新乡医学院
使用产品:Mouse MCP-1, IL-1β and IL-6 ELISA kits
https://pubmed.ncbi.nlm.nih.gov/37804446/
23.文章题目:Screening and identification of potential hypoglycemic and hypolipidemic compounds from aqueous extract of Scutellaria baicalensis Georgi root combing affinity ultrafiltration with multiple drug targets and in silico analysis.
期 刊:Phytochemical Analysis(影响因子:3.3)
发表时间:1 October 2023
作 者:Xu Y, Li Y, Chen G, et al.
作者单位:中国科学院武汉植物园
使用产品:Mouse TNF-α ELISA kit
https://pubmed.ncbi.nlm.nih.gov/37779216/
24.文章题目:evalsuation of Antiviral Activity of Ivermectin against Infectious Bovine Rhinotracheitis Virus in Rabbit Model.
期 刊:Animals(影响因子:3)
发表时间:10 October 2023
作 者:Wang C, Chen Y, Chen X, et al.
作者单位:华中农业大学
使用产品:Bovine IFN-γ, IL-4 and IL-8 ELISA kits
https://www.mdpi.com/2076-2615/13/20/3164
25.文章题目:Possible role of HE4 level elevation in the pathogenesis of TH2-high asthma.
期 刊:Journal of Asthma(影响因子:1.9)
发表时间:30 October 2023
作 者:Kan Zhang ,Yu Cao , B,Hexuan Tang, et al.
作者单位:南京医科大学
使用产品:Human IgE ELISA kit
https://pubmed.ncbi.nlm.nih.gov/37902273/
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