Trofinetide (acetate)-其他肽-ELISA_抗体_蛋白_核苷酸_试剂盒-深圳九游会j9网站首页有限公司

首页产品中心其他肽

Trofinetide (acetate)

品牌：Cayman

官网链接

说明书

折扣/货期

货号：38579-1 mg	规格：1 mg	目录价：￥364
货号：38579-10 mg	规格：10 mg	目录价：￥1820
货号：38579-25 mg	规格：25 mg	目录价：￥4102
货号：38579-5 mg	规格：5 mg	目录价：￥1190

产品详情

产品名称:

Trofinetide (acetate)

别名:

NNZ-2566

产品描述:

Trofinetide is a derivative of the neuroprotective tripeptide Gly-Pro-Glu, an N-terminal sequence found in insulin-like growth factor-1 (IGF-1).{67453} It decreases cell death induced by the protein phosphatase inhibitor okadaic acid (Item No. 10011490) in primary rat embryonic striatal neurons when used at a concentration of 10 nM. Trofinetide reduces brain expression of mRNA encoding IL-1β, TNF-α, IL-6, and E-selectin in a rat model of neuroinflammation induced by a penetrating ballistic-like brain injury.{67454} It reduces cortical and striatal infarct area in a rat model of brain injury induced by middle cerebral artery occlusion (MCAO) when administered at doses of 30 and 60 mg/kg.{67453} Trofinetide (100 mg/kg per day) reduces the number of dendritic spines and reverses deficits in social recognition and contextual fear conditioning, as well as decreases testicular weight gain, in an fmr1-/- knockout mouse model of fragile X syndrome.{67455} Formulations containing trofinetide have been used in the treatment of Rett syndrome.

保存温度:

-20

运输温度:

-20

预期分子量:

315.3

产品形式:

A solid

有效期:

1460

纯度:

≥95%