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折扣/货期| 货号：39624 | 规格：200 µg | 目录价：￥8330 |
产品详情
产品名称:
Thioredoxin Reductase 1 (human, recombinant)
别名:
NADPH-dependent Thioredoxin Reductase|TrxR1|Txnrd1
产品描述:
Thioredoxin reductase 1 (TrxR1) is an oxidoreductase encoded by the TXNRD1 gene in humans and a member of the antioxidant thioredoxin system, which is involved in the maintenance of cellular thiol redox homeostasis.{14257,52830,57136} It exists as a homodimer and contains a dimer interface domain, FAD- and NADPH-binding domains, an N-terminal redox catalytic site, and a C-terminal selenocysteine residue, which is essential for the catalytic activity of TrxR1.{14257,52831} TrxR1 is ubiquitously expressed, localizes to the cytoplasm, and is regulated by the antioxidant transcription factor Nrf2.{52830,52832} TrxR1 catalyzes the NADPH-dependent reduction of oxidized thioredoxin (Trx), restoring the disulfide reductase function of Trx, which regulates redox-sensitive transcription factors, such as NF-κB and p53, and has roles in apoptosis and cell signaling.{57136,52833} Genome-wide deletion of Txnrd1 is embryonic lethal in mice.{52834} Increased serum TrxR1 activity is associated with reduced progression-free survival in patients with non-small cell lung cancer (NSCLC).{52835} Cayman’s Thioredoxin Reductase 1 (human, recombinant) protein can be used for enzyme activity assay.
实验应用:
WB
保存温度:
-20
运输温度:
-20
产品形式:
TE buffer with 50% glycerol
有效期:
365
纯度:
≥95% estimated by SDS-PAGE
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