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Tat-Gap 19 (trifluoroacetate salt)
品牌:Cayman
货号:36729-1 mg 规格:1 mg 目录价:¥3066
货号:36729-5 mg 规格:5 mg 目录价:¥8050
货号:36729-500 µg 规格:500 µg 目录价:¥1610
产品详情
产品名称:
Tat-Gap 19 (trifluoroacetate salt)
产品描述:
Tat-Gap 19 is a peptide inhibitor of connexin43 (Cx43) hemichannels.{59785} It is composed of the HIV-1 Tat protein transduction domain linked to a nine-amino acid peptide corresponding to residues 128-136 of Cx43. Tat-Gap 19 (10 µM) inhibits glutamate-induced ATP release, a marker of Cx43 hemichannel activity, in primary rat hepatocytes.{65897} It reduces infarct volume in a mouse model of cerebral ischemia-reperfusion injury induced by middle cerebral artery occlusion (MCAO) when administered at a dose of 25 mg/kg.{59785} Intraperitoneal infusion of Tat-Gap 19 (1 mg/kg per day) reduces fibrotic lesion area and the area of hepatic stellate cells, precursors of myofibroblasts, expressing α-smooth muscle actin (α-SMA) in a mouse model of thioacetamide-induced liver injury.{65897} It increases superoxide dismutase (SOD) activity in hepatic cells isolated from the same mice.
保存温度:
-20
运输温度:
-20
预期分子量:
2703.3
产品形式:
A solid
有效期:
1460
纯度:
≥95%
分子式:
C119H212N46O26 • XCF3COOH
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