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折扣/货期| 货号：22816 | 规格：100 µg | 目录价：￥8260 |
产品详情
产品名称:
STING R232 variant (human, recombinant)
别名:
Endoplasmic Reticulum Interferon Stimulator|ERIS|Mediator of IRG3 Activation|MITA|Mitochondrial Mediator of IRF3 Activation|MPYS|N-Terminal Methionine-Proline-Tyrpsine-Serine Plasma Membrane Tetraspanner|Stimulator of Interferon Genes|Stimulator of Interferon Response cGAMP Interactor 1|STING1|TMEM173|Transmembrane Protein 173
产品描述:
Stimulator of interferon genes (STING) is a component of the innate immune response that binds to cyclic dinucleotides, which are bacterial second messengers, leading to activation of NF-κB and transcription of immunomodulatory genes, including type I interferon (IFN).{24607,22400,22401,24611} The R232 variant is the most common variant in the human population, found at a frequency of 57.9% in the 1000 Genome Project.{38697} The SNP variant H232 (Item No. 22815) is found at a 13.7% frequency. Various mutations in STING either reduce or increase its activity. Gain-of-function mutations in STING, including R284M (Item No. 23594) and V155M, lead to constitutive activation and enhancement of the type I IFN response.{38697,41598} The V155M mutation is associated with a systemic inflammatory condition, including pulmonary fibrosis and autoimmune factors.{41598} Mutations that reduce STING activity include K224R (Item No. 23593), which reduces ubiquitination of STING thereby disrupting its localization within the cell, and the double mutation G230A, R293Q (Item No. 23592), which reduces the IFN response.{38697,34537} A T596A mutation present in the mouse strain Goldenticket leads to a complete loss of STING protein and lack of a type I IFN response to infection by Listeria.{24612}
保存温度:
-80
运输温度:
-80
产品形式:
50 mM HEPES, pH 8.0, 150 mM sodium chloride, 10% glycerol
有效期:
730
纯度:
≥80% estimated by SDS-PAGE
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