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折扣/货期| 货号：40855-1 mg | 规格：1 mg | 目录价：￥40716 |
| 货号：40855-100 µg | 规格：100 µg | 目录价：￥6264 |
产品详情
产品名称:
Soluble TNFSF15 (human, recombinant)
别名:
sTL1A|TL1|TL1A|TNF Ligand-related Molecule 1|Tumor Necrosis Factor Ligand Superfamily Member 15|Vascular Endothelial Cell Growth Inhibitor|VEGI|VEGI192A
产品描述:
Tumor necrosis factor ligand superfamily member 15 (TNFSF15), also known as TNF ligand-related molecule 1 (TL1A), is a type II transmembrane protein and cognate ligand for TNFRSF25, also known as death domain receptor 3 (DR3), with roles in T cell activation and dendritic cell maturation.{72339,72338} It is composed of a cytoplasmic, a transmembrane, and an extracellular domain and forms membrane-bound non-covalent homotrimers. TNFSF15 exists primarily in its membrane-bound form, but can be cleaved by matrix metalloproteinases (MMPs) to release the soluble form (sTL1A).{72339,72340} Both membrane-bound and soluble TNFSF15 bind to TNFRSF25 on the surface of T cells, inducing various signaling pathways resulting in NF-κB activation or apoptosis.{72340} TNFSF15 also binds to TNF receptor 2 (TNFR2) and TNFR6B, also known as soluble decoy receptor 3 (DcR3), on the surface of T cells to induce pro-inflammatory cytokine production and the inhibition of apoptosis. Intestinal levels of TNFSF15 are increased in patients with inflammatory bowel disease (IBD).{72337} TNFSF15 SNPs are associated with an increased susceptibility to developing small cell lung cancer (SCLC).{72336} Cayman’s Soluble TNFSF15 (human, recombinant) protein consists of 199 amino acids and has a calculated molecular weight of 22.8 kDa.
宿主来源:
HEK293 cells
保存温度:
-80
运输温度:
-80
产品形式:
Lyophilized from sterile PBS, pH 7.4
有效期:
365
纯度:
≥95% estimated by SDS-PAGE
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