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折扣/货期| 货号：10315 | 规格：100 µg | 目录价：￥6216 |
产品详情
产品名称:
SIRT6 (human, recombinant)
别名:
NAD-dependent Deacetylase 6|Silent Information Regulator 6|SIR2-like Protein 6|SIR2L6|Sirtuin 6
产品描述:
The sirtuins represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs) and have been shown to catalyze a reaction that couples lysine deacetylation to the formation of nicotinamide and O-acetyl-ADP-ribose from NAD+ and the abstracted acetyl group.{15271,15275,15273} There are seven human sirtuins, which have been designated SIRT1-7.{15274} SIRT6 associates specifically with telomeres and functions at chromatin to decrease NF-κB signaling.{17071,15626} Mammalian cells depleted of SIRT6 display abnormal telomere structures similar to defects found in Werner syndrome, a premature ageing disorder, and have a shortened life span.{17071,15626} Since SIRT6 binds and attenuates NF-κB signaling, it is proposed that activators of SIRT6 may be effective anti-cancer and anti-inflammatory drugs and may increase longevity.{17071}
保存温度:
-80
运输温度:
-80
产品形式:
25 mM Tris-HCl, pH 8.0, with 100mM NaCl, 20% glycerol
有效期:
545
纯度:
≥80% estimated by SDS-PAGE
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