货号:10320 | 规格:500 µg | 目录价:¥8414 |
产品详情
产品名称:
SET7/9 (human recombinant)
别名:
KMT7|SET Domain-containing Protein 7/9|SETD7|SETD7/9
产品描述:
Methylation of lysine can promote transcriptional activation or repression and is critical in regulating histone function.{17223} Lysine residues can be mono-, di-, or tri-methylated, and unlike most SET proteins, SET7/9 is exclusively a mono-methylase.{17224} SET7/9 methylates histone H3, tumor suppressor p53, and transcription factor TAF10.{16846} Recently, SET7/9 was shown to catalyze methylation of p53 in response to DNA damage thereby activating p53 for subsequent acetylation.{17223} SET7/9 is able to modulate p53 activity in a human cancer cell line, implying that it may play a significant role in human tumorigenesis.
保存温度:
-80
运输温度:
-80
产品形式:
50 mM HEPES, pH 7.2, 100 mM sodium chloride, and 20% glycerol
有效期:
180
纯度:
≥95% estimated by SDS-PAGE
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